Browsing Centre for Biochemical Pharmacology by Author "Tabas, I"
Now showing items 1-5 of 5
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An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo.
Subramanian, M; Hayes, CD; Thome, JJ; Thorp, E; Matsushima, GK; Herz, J; Farber, DL; Liu, K; Lakshmana, M; Tabas, I (2014-03)The phagocytosis of apoptotic cells (ACs), or efferocytosis, by DCs is critical for self-tolerance and host defense. Although many efferocytosis-associated receptors have been described in vitro, the functionality of these ... -
Identification of a non-growth factor role for GM-CSF in advanced atherosclerosis: promotion of macrophage apoptosis and plaque necrosis through IL-23 signaling.
Subramanian, M; Thorp, E; Tabas, I (2015-01-16)RATIONALE: Granulocyte macrophage colony-stimulating factor (GM-CSF, Csf2) is a growth factor for myeloid-lineage cells that has been implicated in the pathogenesis of atherosclerosis and other chronic inflammatory diseases. ... -
Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction.
DeBerge, M; Glinton, K; Subramanian, M; Wilsbacher, LD; Rothlin, CV; Tabas, I; Thorp, EB (2021-02-02)Tyro3, AXL, and MerTK (TAM) receptors are activated in macrophages in response to tissue injury and as such have been proposed as therapeutic targets to promote inflammation resolution during sterile wound healing, including ... -
Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages.
Wang, Y; Subramanian, M; Yurdagul, A; Barbosa-Lorenzi, VC; Cai, B; de Juan-Sanz, J; Ryan, TA; Nomura, M; Maxfield, FR; Tabas, I (2017-10-05)Clearance of apoptotic cells (ACs) by phagocytes (efferocytosis) prevents post-apoptotic necrosis and dampens inflammation. Defective efferocytosis drives important diseases, including atherosclerosis. For efficient ... -
Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice
Fredman, G; Kamaly, N; Spolitu, S; Milton, J; Ghorpade, D; Chiasson, R; Kuriakose, G; Perretti, M; Farokzhad, O; Tabas, I (2015-02-18)