Browsing Centre for Biochemical Pharmacology by Author "Subramanian, M"
Now showing items 1-10 of 10
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An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo.
Subramanian, M; Hayes, CD; Thome, JJ; Thorp, E; Matsushima, GK; Herz, J; Farber, DL; Liu, K; Lakshmana, M; Tabas, I (2014-03)The phagocytosis of apoptotic cells (ACs), or efferocytosis, by DCs is critical for self-tolerance and host defense. Although many efferocytosis-associated receptors have been described in vitro, the functionality of these ... -
CD36 pumps fat to defang killer T cells in tumors
Subramanian, M; Marelli-Berg, FM (2021-08-03) -
Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling
Bhattacharya, P; Dhawan, UK; Hussain, MT; Singh, P; Bhagat, KK; Singhal, A; Austin-Williams, S; Sengupta, S; Subramanian, M (2023) -
Hypercholesterolemia Impairs Clearance of Neutrophil Extracellular Traps and Promotes Inflammation and Atherosclerotic Plaque Progression.
Dhawan, UK; Bhattacharya, P; Narayanan, S; Manickam, V; Aggarwal, A; Subramanian, M (2021-08-05)OBJECTIVE: Hypercholesterolemia-induced NETosis and accumulation of neutrophil extracellular traps (NETs) in the atherosclerotic lesion exacerbates inflammation and is causally implicated in plaque progression. We investigated ... -
Hypercholesterolemia promotes autoantibody production and a lupus-like pathology via decreased DNase-mediated clearance of DNA
Dhawan, UK; Margraf, A; Lech, M; Subramanian, M (2022) -
Identification of a non-growth factor role for GM-CSF in advanced atherosclerosis: promotion of macrophage apoptosis and plaque necrosis through IL-23 signaling.
Subramanian, M; Thorp, E; Tabas, I (2015-01-16)RATIONALE: Granulocyte macrophage colony-stimulating factor (GM-CSF, Csf2) is a growth factor for myeloid-lineage cells that has been implicated in the pathogenesis of atherosclerosis and other chronic inflammatory diseases. ... -
Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction.
DeBerge, M; Glinton, K; Subramanian, M; Wilsbacher, LD; Rothlin, CV; Tabas, I; Thorp, EB (2021-02-02)Tyro3, AXL, and MerTK (TAM) receptors are activated in macrophages in response to tissue injury and as such have been proposed as therapeutic targets to promote inflammation resolution during sterile wound healing, including ... -
Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages.
Wang, Y; Subramanian, M; Yurdagul, A; Barbosa-Lorenzi, VC; Cai, B; de Juan-Sanz, J; Ryan, TA; Nomura, M; Maxfield, FR; Tabas, I (2017-10-05)Clearance of apoptotic cells (ACs) by phagocytes (efferocytosis) prevents post-apoptotic necrosis and dampens inflammation. Defective efferocytosis drives important diseases, including atherosclerosis. For efficient ... -
Pomegranate Peel Extract Decreases Plaque Necrosis and Advanced Atherosclerosis Progression in Apoe(-/-) Mice
Manickam, V; Dhawan, UK; Singh, D; Gupta, M; Subramanian, M (2022) -
Resolution pharmacology-A fresh approach to the clinical management of human inflammatory diseases
Perretti, M; Subramanian, M (2023)