Browsing Centre for Biochemical Pharmacology by Author "Shattock, MJ"
Now showing items 1-4 of 4
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Intracellular sodium elevation reprograms cardiac metabolism.
Aksentijević, D; Karlstaedt, A; Basalay, MV; O'Brien, BA; Sanchez-Tatay, D; Eminaga, S; Thakker, A; Tennant, DA; Fuller, W; Eykyn, TR (2020-08-28)Intracellular Na elevation in the heart is a hallmark of pathologies where both acute and chronic metabolic remodelling occurs. Here, we assess whether acute (75 μM ouabain 100 nM blebbistatin) or chronic myocardial Nai ... -
Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?
Aksentijevic, D; O'Brien, BA; Eykyn, TR; Shattock, MJ (2018) -
Mechanism of succinate efflux upon reperfusion of the ischemic heart.
Prag, HA; Gruszczyk, AV; Huang, MM; Beach, TE; Young, T; Tronci, L; Nikitopoulou, E; Mulvey, JF; Ascione, R; Hadjihambi, A (2020-08-07)AIMS: Succinate accumulates several-fold in the ischemic heart and is then rapidly oxidised upon reperfusion, contributing to reactive oxygen species (ROS) production by mitochondria. In addition, a significant amount of ... -
With a grain of salt: Sodium elevation and metabolic remodelling in heart failure.
Aksentijević, D; Shattock, MJ (2021-08-06)Elevated intracellular Na (Nai) and metabolic impairment are interrelated pathophysiological features of the failing heart (HF). There have been a number of studies showing that myocardial sodium elevation subtly affects ...