Browsing Centre for Biochemical Pharmacology by Author "Pfeffer, PE"
Now showing items 1-20 of 31
-
Association between pre-biologic T2-Biomaker combinations and response to biologics in patients with severe asthma
Porsbjerg, CM; Townend, J; Bergeron, C; Christoff, GC; Katsoulotos, GP; Larenas-Linnemann, D; Tran, TN; Al-Lehebi, R; Bosnic-Anticevich, SZ; Busby, J -
An association between pulmonary Mycobacterium avium-intracellulare complex infections and biomarkers of Th2-type inflammation
Pfeffer, PE; Hopkins, S; Cropley, I; Lowe, DM; Lipman, M (2017-05-15) -
Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma.
Wechsler, ME; Scelo, G; Larenas-Linnemann, DES; Torres-Duque, CA; Maspero, J; Tran, TN; Murray, RB; Martin, N; Menzies-Gow, AN; Hew, M (2023-11-28)RATIONALE: Previous studies investigating comorbidity impact on biologic effectiveness have been relatively small, of short duration, and have not compared biologic classes. OBJECTIVES: To determine the association between ... -
Biomarker-defined clusters by level of Type 2 inflammatory involvement in severe asthma
Price, D; Burkill, S; Wang, E; Wechsler, ME; Denton, E; Tran, TN; Martin, N; Katial, R; Barker, P; Maspero, J (2022) -
Bringing the treatable traits approach to primary care asthma management
Pfeffer, PE; Rupani, H; De Simoni, A -
Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era.
Jackson, DJ; Busby, J; Pfeffer, PE; Menzies-Gow, A; Brown, T; Gore, R; Doherty, M; Mansur, AH; Message, S; Niven, R (BMJ, 2020-12-09)BACKGROUND: The UK Severe Asthma Registry (UKSAR) is the world's largest national severe asthma registry collecting standardised data on referrals to UK specialist services. Novel biologic therapies have transformed the ... -
CHARACTERISTICS OF PATIENTS IN THE UK SEVERE ASTHMA REGISTRY: VARIATION BY ETHNICITY
Busby, J; Jackson, DJ; Mansur, AH; Menzies-Gow, A; Heaney, LG; Chaudhuri, R; Pfeffer, PE (2019-11-12)Abstract P152 from British Thoracic Society Winter Meeting 2019, QEII Centre, Broad Sanctuary, Westminster, London SW1P 3EE, 4 to 6 December 2019 -
Clinical Effectiveness of Benralizumab Is Independent of Baseline FeNO in Severe Eosinophilic Asthma: A Retrospective Real-World Observation Study in Five UK Severe Asthma Centers
Jackson, DJ; Burhan, H; Menzies-Gow, A; Pfeffer, PE; Nanzer, A; Gil, EG; Morris, T; Tran, TN; Hirsch, I; Dube, S (2021-05-01) -
Comparative effectiveness of Anti-IL5 and Anti-IgE biologic classes in patients with severe asthma eligible for both
Pfeffer, PE; Ali, N; Murray, R; Ulrik., C; Tran, TN; Maspero, J; Peters, M; Christoff, GC; Sadatsafavi, M; Torres-Duque, CA (2023) -
The effects of oral corticosteroids on lung function, type-2 biomarkers and patient-reported outcomes in stable asthma: A systematic review and meta-analysis.
Busby, J; Khoo, E; Pfeffer, PE; Mansur, AH; Heaney, LG (2020-09-14)BACKGROUND: Several studies have investigated the physiological effect of OCS in stable asthma, however these have included heterogeneous populations and outcomes. This paper is the first to combine their results. METHODS: ... -
Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter
Pfeffer, PE; Lu, H; Mann, EH; Chen, Y-H; Ho, T-R; Cousins, DJ; Corrigan, C; Kelly, FJ; Mudway, IS; Hawrylowicz, CM (2018-08-29) -
Eosinophilic and non-eosinophilic asthma: an expert consensus framework to characterize phenotypes in a global real-life severe asthma cohort.
Heaney, LG; Perez de Llano, L; Al-Ahmad, M; Backer, V; Busby, J; Canonica, GW; Christoff, GC; Cosio, BG; FitzGerald, JM; Heffler, E (2021-04-19)BACKGROUND: Phenotypic characteristics of eosinophilic and non-eosinophilic asthma patients are not well-characterized in global, real life severe asthma cohorts. RESEARCH QUESTION: What is the prevalence of eosinophilic ... -
Exploring definitions and predictors of response to biologics for severe asthma.
Scelo, G; Tran, TN; Le, TT; Faregås, M; Dorscheid, D; Busby, J; Al-Ahmad, M; Al-Lehebi, R; Altraja, A; Beastall, A (Elsevier, 2024-05-19)BACKGROUND: Biologic effectiveness is often assessed as 'response', a term which eludes consistent definition. Identifying those most likely to respond in real-life has proven challenging. OBJECTIVE: To explore definitions ... -
Exploring Definitions and Predictors of Severe Asthma Clinical Remission Post-Biologic in Adults.
Perez-de-Llano, L; Scelo, G; Tran, TN; Le, TT; Faregås, M; Cosio, BG; Peters, M; Pfeffer, PE; Al-Ahmad, M; Al-Lehebi, RO (American Thoracic Society, 2024-05-03)RATIONALE: There is no consensus on criteria to include in an asthma remission definition in real-life. Factors associated with achieving remission post-biologic-initiation remain poorly understood. OBJECTIVES: To quantify ... -
Factors associated with frequent exacerbations in the UK Severe Asthma Registry.
Yang, F; Busby, J; Heaney, LG; Menzies-Gow, A; Pfeffer, PE; Jackson, DJ; Mansur, AH; Siddiqui, S; Brightling, CE; Niven, R (Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology, 2021-01-15)BACKGROUND: Frequent exacerbations are an important cause of morbidity in patients with severe asthma. OBJECTIVE: Our aim was to identify factors associated with frequent exacerbations in a large well-characterized severe ... -
Identification of autoantigens and their potential post-translational modification in EGPA and severe eosinophilic asthma
Esposito, I; Kontra, I; Giacomassi, C; Manou-Stathopoulou, S; Brown, J; Stratton, R; Verykokou, G; Buccafusca, R; Stevens, M; Nissim, A (2023) -
Impact of comorbidities on EQ5D quality of life index in severe asthma
Pfeffer, PE; Brown, T; Chaudhuri, R; Faruqi, S; Gore, R; Heaney, L; Mansur, AH; Pantin, T; Patel, M; Rupani, H (Elsevier, 2024-05-31) -
Impact of Initiating Biologics in Patients With Severe Asthma on Long-Term Oral Corticosteroids or Frequent Rescue Steroids (GLITTER): Data From the International Severe Asthma Registry.
Chen, W; Tran, TN; Sadatsafavi, M; Murray, R; Wong, NCB; Ali, N; Ariti, C; Bulathsinhala, L; Gil, EG; FitzGerald, JM (2023-09)BACKGROUND: Effectiveness of biologics has neither been established in patients with high oral corticosteroid exposure (HOCS) nor been compared with effectiveness of continuing with HOCS alone. OBJECTIVE: To examine the ... -
The impact of the first COVID-19 surge on severe asthma patients in the UK. Which is worse: the virus or the lockdown?
Smith, SJ; Busby, J; Heaney, LG; Pfeffer, PE; Jackson, DJ; Yang, F; Fowler, SJ; Menzies-Gow, A; Idris, E; Brown, T (2021-01)Asthma therapy, including monoclonal antibodies, was not associated with #COVID19 infection or hospitalisation in a UK severe asthma population. Shielding led to a reported worsening of mental health in nearly half of ... -
Increased Chronic Obstructive Pulmonary Disease Exacerbations of Likely Viral Etiology Follow Elevated Ambient Nitrogen Oxides
Pfeffer, PE; Donaldson, GC; Mackay, AJ; Wedzicha, JA (2019-03-01)