Browsing Centre for Biochemical Pharmacology by Author "Laitinen, S"
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Lipid mediators in platelet concentrate and extracellular vesicles: Molecular mechanisms from membrane glycerophospholipids to bioactive molecules.
Valkonen, S; Holopainen, M; Colas, RA; Impola, U; Dalli, J; Käkelä, R; Siljander, PR-M; Laitinen, S (2019-08)Platelets are collected for transfusion to patients with different haematological disorders, and for logistical reasons, platelets are stored as concentrates. Despite carefully controlled conditions, platelets become ... -
Polyunsaturated fatty acids modify the extracellular vesicle membranes and increase the production of proresolving lipid mediators of human mesenchymal stromal cells.
Holopainen, M; Colas, RA; Valkonen, S; Tigistu-Sahle, F; Hyvärinen, K; Mazzacuva, F; Lehenkari, P; Käkelä, R; Dalli, J; Kerkelä, E (2019-10)Human mesenchymal stromal/stem cells (hMSCs) are used in experimental cell therapy to treat various immunological disorders, and the extracellular vesicles (hMSC-EVs) they produce have emerged as an option for cell-free ...