Browsing Centre for Biochemical Pharmacology by Author "James, AM"
Now showing items 1-3 of 3
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Mechanism of succinate efflux upon reperfusion of the ischemic heart.
Prag, HA; Gruszczyk, AV; Huang, MM; Beach, TE; Young, T; Tronci, L; Nikitopoulou, E; Mulvey, JF; Ascione, R; Hadjihambi, A (2020-08-07)AIMS: Succinate accumulates several-fold in the ischemic heart and is then rapidly oxidised upon reperfusion, contributing to reactive oxygen species (ROS) production by mitochondria. In addition, a significant amount of ... -
Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury
Miljkovic, JL; Burger, N; Gawel, JM; Mulvey, JF; Norman, AAI; Nishimura, T; Tsujihata, Y; Logan, A; Sauchanka, O; Caldwell, ST (2022) -
Structural basis for a complex I mutation that blocks pathological ROS production.
Yin, Z; Burger, N; Kula-Alwar, D; Aksentijević, D; Bridges, HR; Prag, HA; Grba, DN; Viscomi, C; James, AM; Mottahedin, A (2021-01-29)Mitochondrial complex I is central to the pathological reactive oxygen species (ROS) production that underlies cardiac ischemia-reperfusion (IR) injury. ND6-P25L mice are homoplasmic for a disease-causing mtDNA point ...