Browsing Centre for Biochemical Pharmacology by Author "Aksoy, E"
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From Welfare to Warfare: The Arbitration of Host-Microbiota Interplay by the Type VI Secretion System.
Wood, TE; Aksoy, E; Hachani, A (Frontiers Media, 2020)The health of mammals depends on a complex interplay with their microbial ecosystems. Compartments exposed to external environments such as the mucosal surfaces of the gastrointestinal tract accommodate the gut microbiota, ... -
The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function.
Aksoy, E; Saveanu, L; Manoury, B (2018)Phosphoinositide-3 kinases (PI3Ks) generate 3-phosphorylated phosphoinositide lipids that are implicated in many biological processes in homeostatic states and pathologies such as cancer, inflammation and autoimmunity. ... -
Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR (vol 177, pg 1201, 2019)
Mogilenko, DA; Haas, JT; L'homme, L; Fleury, S; Quemener, S; Levavasseur, M; Becquart, C; Wartelle, J; Bogomolova, A; Pineau, L (2019-06-27) -
NF-κB activation and severity of gastritis in Helicobacter pylori-infected children and adults.
Bontems, P; Aksoy, E; Burette, A; Segers, V; Deprez, C; Mascart, F; Cadranel, S (2014-06)BACKGROUND: In contrast to adults, Helicobacter pylori gastritis in children is reported as milder and ulcer disease as uncommon, but unequivocal data are lacking. OBJECTIVES: To compare the frequency of gastro-duodenal ... -
Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component.
Thibault, B; Ramos-Delgado, F; Pons-Tostivint, E; Therville, N; Cintas, C; Arcucci, S; Cassant-Sourdy, S; Reyes-Castellanos, G; Tosolini, M; Villard, AV (EMBO Press, 2021-05-25)Pancreatic ductal adenocarcinoma (PDAC) patients frequently suffer from undetected micro-metastatic disease. This clinical situation would greatly benefit from additional investigation. Therefore, we set out to identify ... -
TLRs toll for Tregs.
Aksoy, E (2019-12)Discussion on TLR3 triggering in CD4 T cells induces IFN beta and IL10-producing iTregs that suppress food allergy. -
Transient Inhibition of PI3K delta Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus
Ferguson, MS; Dunmall, LSC; Gangeswaran, R; Marelli, G; Tysome, JR; Burns, E; Whitehead, MA; Aksoy, E; Alusi, G; Hiley, C (2020-05-06)