Browsing Centre for Biochemical Pharmacology by Title
Now showing items 290-309 of 333
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S25 The impact of COVID-19 on the UK severe asthma population
(BMJ, 2021-02) -
Senescence under appraisal: hopes and challenges revisited.
(Springer Nature, 2021-01-13)In recent years, cellular senescence has become the focus of attention in multiple areas of biomedical research. Typically defined as an irreversible cell cycle arrest accompanied by increased cellular growth, metabolic ... -
Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy.
(2023-06)BACKGROUND: The phase IIIb, randomized, parallel-group, placebo-controlled ANDHI double-blind (DB) study extended understanding of the efficacy of benralizumab for patients with severe eosinophilic asthma. Patients from ... -
Smile-It's in your blood!
(2014-10-01) -
Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs
(Frontiers Media, 2021-03-29)Neuromodulation of the immune system has been proposed as a novel therapeutic strategy for the treatment of inflammatory conditions. We recently demonstrated that stimulation of near-organ autonomic nerves to the spleen ... -
Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA.
(2017-10-18)PD1n-3 DPA is a specialized pro-resolving lipid mediator that displays potent anti-inflammatory properties and pro-resolving bioactivities. Such naturally occurring compounds are of current interest in biomolecular chemistry ... -
Stereoselective synthesis of MaR2(n-3) (DPA)
(2020-02-13) -
Structural basis for a complex I mutation that blocks pathological ROS production.
(2021-01-29)Mitochondrial complex I is central to the pathological reactive oxygen species (ROS) production that underlies cardiac ischemia-reperfusion (IR) injury. ND6-P25L mice are homoplasmic for a disease-causing mtDNA point ... -
A subset of CCL25-induced gut-homing T cells affects intestinal immunity to infection and cancer.
Protective immunity relies upon differentiation of T cells into the appropriate subtype required to clear infections and efficient effector T cell localization to antigen-rich tissue. Recent studies have highlighted the ...