Browsing Centre for Biochemical Pharmacology by Title
Now showing items 197-216 of 333
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Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction.
(2021-02-02)Tyro3, AXL, and MerTK (TAM) receptors are activated in macrophages in response to tissue injury and as such have been proposed as therapeutic targets to promote inflammation resolution during sterile wound healing, including ... -
Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production.
(Royal Society of Chemistry, 2020-03-25)Nanoengineered vehicles have the potential to deliver cargo drugs directly to disease sites, but can potentially be cleared by immune system cells or lymphatic drainage. In this study we explore the use of magnetism to ... -
Massage-like stroking boosts the immune system in mice
(2015-06-05) -
MAY INFLAMMATION BE WITH YOU!
(Frontiers Media SA, 2018-09-21)The Pillars of Inflammation The word inflammation comes from the Latin word inflammare (meaning “to set on fire”). The Roman writer Aulus Cornelius Celsus, who lived in the 1st century AD, was the first to describe the ... -
Mechanism of succinate efflux upon reperfusion of the ischemic heart.
(2020-08-07)AIMS: Succinate accumulates several-fold in the ischemic heart and is then rapidly oxidised upon reperfusion, contributing to reactive oxygen species (ROS) production by mitochondria. In addition, a significant amount of ... -
Mechanisms of T cell organotropism
(2016-08) -
Melanocortin receptors as novel effectors of macrophage responses in inflammation.
(2011)Macrophages have crucial functions in initiating the inflammatory reaction in a strict temporal and spatial manner to provide a "clear-up" response required for resolution. Hormonal peptides such as melanocortins modulate ... -
Mesoglycan connects Syndecan-4 and VEGFR2 through Annexin A1 and formyl peptide receptors to promote angiogenesis in vitro.
(2021-05-31)Mesoglycan is a mixture of glycosaminoglycans (GAG) with fibrinolytic effects and the potential to enhance skin wound repair. Here, we have used endothelial cells isolated from Wild Type (WT) and Syndecan-4 null (Sdc4-/-) ... -
A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing.
(2023-05-25)BACKGROUND: Many genes associated with asthma explain only a fraction of its heritability. Most genome-wide association studies (GWASs) used a broad definition of 'doctor-diagnosed asthma', thereby diluting genetic signals ...