Browsing Centre for Biochemical Pharmacology by Title
Now showing items 100-119 of 333
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ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages.
(2018-10-16)BACKGROUND: In addition to enhanced proinflammatory signaling, impaired resolution of vascular inflammation plays a key role in atherosclerosis. Proresolving lipid mediators formed through the 12/15 lipoxygenase pathways ... -
Evaluation of Competing Methodologies for In Vivo Tracking of Human Regulatory T Cells Intended for Adoptive Cell Therapy in Transplantation
(2021-04-27)Meeting Abstract 792 from ASGCT Annual Meeting Abstracts -
Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma.
(2017-11-24)Following peripheral axon injury, dysregulation of non-coding microRNAs (miRs) occurs in dorsal root ganglia (DRG) sensory neurons. Here we show that DRG neuron cell bodies release extracellular vesicles, including exosomes ... -
Expert Consensus on the Tapering of Oral Corticosteroids for the Treatment of Asthma A Delphi Study
(American Thoracic Society, 2021-04-01) -
Exploring definitions and predictors of response to biologics for severe asthma.
(Elsevier, 2024-05-19)BACKGROUND: Biologic effectiveness is often assessed as 'response', a term which eludes consistent definition. Identifying those most likely to respond in real-life has proven challenging. OBJECTIVE: To explore definitions ... -
Exploring Definitions and Predictors of Severe Asthma Clinical Remission Post-Biologic in Adults.
(American Thoracic Society, 2024-05-03)RATIONALE: There is no consensus on criteria to include in an asthma remission definition in real-life. Factors associated with achieving remission post-biologic-initiation remain poorly understood. OBJECTIVES: To quantify ... -
Expression of ACKR4 demarcates the "peri-marginal sinus," a specialized vascular compartment of the splenic red pulp.
(2021-07-13)The spleen comprises defined microanatomical compartments that uniquely contribute to its diverse host defense functions. Here, we identify a vascular compartment within the red pulp of the spleen delineated by expression ... -
Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity
(Wiley, 2021-04-27)Extracellular vesicles (EVs) are emerging as key players in different stages of atherosclerosis. Here we provide evidence that EVs released by mixed aggregates of monocytes and platelets in response to TNF-α display ... -
Factors associated with frequent exacerbations in the UK Severe Asthma Registry.
(Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology, 2021-01-15)BACKGROUND: Frequent exacerbations are an important cause of morbidity in patients with severe asthma. OBJECTIVE: Our aim was to identify factors associated with frequent exacerbations in a large well-characterized severe ... -
Feasibility of real-time capture of routine clinical data in the electronic health record: a hospital-based, observational service-evaluation study.
(2018-03-08)OBJECTIVES: The electronic health record (EHR) is underused in the hospital setting. The aim of this service evaluation study was to respond to National Health Service (NHS) Digital's ambition for a paperless NHS by capturing ... -
Findings of Impaired Hearing in Patients With Nonfluent/Agrammatic Variant Primary Progressive Aphasia.
(American Medical Association, 2019-02-11)Importance: Despite being characterized as a disorder of language production, nonfluent/agrammatic variant primary progressive aphasia (nfvPPA) is frequently associated with auditory symptoms. However, to our knowledge, ... -
From Welfare to Warfare: The Arbitration of Host-Microbiota Interplay by the Type VI Secretion System.
(Frontiers Media, 2020)The health of mammals depends on a complex interplay with their microbial ecosystems. Compartments exposed to external environments such as the mucosal surfaces of the gastrointestinal tract accommodate the gut microbiota, ...