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A weighted burden test using logistic regression for integrated analysis of sequence variants, copy number variants and polygenic risk score.
(2019-01)
Previously described methods of analysis allow variants in a gene to be weighted more highly according to rarity and/or predicted function and then for the variant contributions to be summed into a gene-wise risk score, ...
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
(Springer Nature, 2019-03-25)
Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex ...
Pursuing parity: genetic tests for psychiatric conditions in the UK National Health Service.
(2019-05)
Schizophrenia and anorexia nervosa were recently added to the list of conditions for which whole genome sequencing might be indicated as part of the 100 000 Genomes Project, reflecting the remarkable recent progress in ...
A polygenic resilience score moderates the genetic risk for schizophrenia.
(2019-09-06)
Based on the discovery by the Resilience Project (Chen R. et al. Nat Biotechnol 34:531-538, 2016) of rare variants that confer resistance to Mendelian disease, and protective alleles for some complex diseases, we posited ...