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Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
(Springer Nature, 2019-03-25)
Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex ...
A polygenic resilience score moderates the genetic risk for schizophrenia.
(2019-09-06)
Based on the discovery by the Resilience Project (Chen R. et al. Nat Biotechnol 34:531-538, 2016) of rare variants that confer resistance to Mendelian disease, and protective alleles for some complex diseases, we posited ...