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Accelarated immune ageing is associated with COVID-19 disease severity.
(2024-01-11)BACKGROUND: The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convalescent ... -
Age stratified, matched comparison of unicompartmental and total knee replacement.
(2020-10)BACKGROUND: Unicompartmental knee replacement (UKR) tends to provide better function but has a higher revision rate than total knee replacement (TKR). The aim was to determine if this occurred in all age groups. METHODS: ... -
Alternative developmental and transcriptomic responses to host plant water limitation in a butterfly metapopulation.
(2022-11)Predicting how climate change affects biotic interactions poses a challenge. Plant-insect herbivore interactions are particularly sensitive to climate change, as climate-induced changes in plant quality cascade into the ... -
Alternative splicing in seasonal plasticity and the potential for adaptation to environmental change.
(2022-02-08)Seasonal plasticity is accomplished via tightly regulated developmental cascades that translate environmental cues into trait changes. Little is known about how alternative splicing and other posttranscriptional molecular ... -
Amino Acids Whose Intracellular Levels Change Most During Aging Alter Chronological Life Span of Fission Yeast.
(Oxford University Press, 2020-11-03)Amino acid deprivation or supplementation can affect cellular and organismal life span, but we know little about the role of concentration changes in free, intracellular amino acids during aging. Here, we determine free ... -
Antibacterial efficacy of indigenous Pakistani honey against extensively drug-resistant clinical isolates of Salmonella enterica serovar Typhi: an alternative option to combat antimicrobial resistance
(BMC, 2023-02-08)Abstract Background Extensively drug-resistant (XDR) Salmonella enterica serovar Typhi (S. Typhi) poses a grave threat to public health due to increased mortality and morbidity caused by typhoid fever. Honey is a promising ... -
B Cell Mobilization, Dissemination, Fine Tuning of Local Antigen Specificity and Isotype Selection in Asthma.
(Frontiers Media, 2021-10-14)In order to better understand how the immune system interacts with environmental triggers to produce organ-specific disease, we here address the hypothesis that B and plasma cells are free to migrate through the mucosal ... -
B-cell-specific checkpoint molecules that regulate anti-tumour immunity.
(2023-07)The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cytometry ... -
Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy.
(2022-08-27)Voltage-gated calcium (CaV) channels form three subfamilies (CaV1-3). The CaV1 and CaV2 channels are heteromeric, consisting of an α1 pore-forming subunit, associated with auxiliary CaVβ and α2δ subunits. The α2δ subunits ... -
Bioinspired Bi2O3-ZrO2 nanocomposite heterojunction as energy storage material and high-performance electrocatalyst for water oxidation
(Springer, 2024-01-13)Phyto-mediated nanocomposite materials possess significant potential in morphological control as well as in electrocatalytic activity, which is the main reason for steered interest in the design of new materials for their ... -
Bionic design of multi-scale superhydrophobic textures to smash impacted droplets: An anti-icing strategy
(Elsevier, 2024-04-16)The ice formed on aircraft as a result of the freezing of supercooled large droplets (SLD) presents a significant safety risk to flight safety. Mitigating or inhibiting SLD icing has attracted considerable attention from ... -
Bioorthogonal Swarming: In Situ Generation of Dendrimers
(American Chemical Society, 2020-12-16)With the aid of bioorthogonal chemistry, we demonstrate the fabrication of synthetic dendrimers in situ around living cells. Using tetrazine dienophile and aminooxyl/hydrazide aldehyde chemistries, the density of functional ... -
A bovine miRNA, bta-miR-154c, withstands in vitro human digestion but does not affect cell viability of colorectal human cell lines after transfection
(Wiley Open Access, 2022-03-23)Colorectal cancer (CRC) is the third most frequent human cancer with over 1.3 million new cases globally. CRC is a complex disease caused by interactions between genetic and environmental factors; in particular, high ...