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Now showing items 13-32 of 247
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B Cell Mobilization, Dissemination, Fine Tuning of Local Antigen Specificity and Isotype Selection in Asthma.
(Frontiers Media, 2021-10-14)In order to better understand how the immune system interacts with environmental triggers to produce organ-specific disease, we here address the hypothesis that B and plasma cells are free to migrate through the mucosal ... -
B-cell-specific checkpoint molecules that regulate anti-tumour immunity.
(2023-07)The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cytometry ... -
Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy.
(2022-08-27)Voltage-gated calcium (CaV) channels form three subfamilies (CaV1-3). The CaV1 and CaV2 channels are heteromeric, consisting of an α1 pore-forming subunit, associated with auxiliary CaVβ and α2δ subunits. The α2δ subunits ... -
Bioinspired Bi2O3-ZrO2 nanocomposite heterojunction as energy storage material and high-performance electrocatalyst for water oxidation
(Springer, 2024-01-13)Phyto-mediated nanocomposite materials possess significant potential in morphological control as well as in electrocatalytic activity, which is the main reason for steered interest in the design of new materials for their ... -
Bionic design of multi-scale superhydrophobic textures to smash impacted droplets: An anti-icing strategy
(Elsevier, 2024-04-16)The ice formed on aircraft as a result of the freezing of supercooled large droplets (SLD) presents a significant safety risk to flight safety. Mitigating or inhibiting SLD icing has attracted considerable attention from ... -
Bioorthogonal Swarming: In Situ Generation of Dendrimers
(American Chemical Society, 2020-12-16)With the aid of bioorthogonal chemistry, we demonstrate the fabrication of synthetic dendrimers in situ around living cells. Using tetrazine dienophile and aminooxyl/hydrazide aldehyde chemistries, the density of functional ... -
A bovine miRNA, bta-miR-154c, withstands in vitro human digestion but does not affect cell viability of colorectal human cell lines after transfection
(Wiley Open Access, 2022-03-23)Colorectal cancer (CRC) is the third most frequent human cancer with over 1.3 million new cases globally. CRC is a complex disease caused by interactions between genetic and environmental factors; in particular, high ... -
Brain webs for brane webs
(2022-10-10)We propose a new technique for classifying 5d Superconformal Field Theories arising from brane webs in Type IIB String Theory, using technology from Machine Learning to identify different webs giving rise to the same theory. ... -
Caloric Restriction per se Rather Than Dietary Macronutrient Distribution Plays a Primary Role in Metabolic Health and Body Composition Improvements in Obese Mice.
(MDPI, 2021-08-28)Caloric restriction (CR) is of key importance in combating obesity and its associated diseases. We aimed to examine effects of dietary macronutrient distribution on weight loss and metabolic health in obese mice exposed ... -
Capacitive PVC Gel Pressure Sensors with Various Interlinked Microstructural Dielectric Middle Layers
(Elsevier, 2024-05-22)Our sharp tactile sense is largely attributable to an undulating layer of microstructures between the epidermis and dermis, amplifying tactile signals. Taking inspiration from the biological template, we propose a design ... -
Case Review: Whole-Exome Sequencing Analyses Identify Carriers of a Known Likely Pathogenic Intronic BRCA1 Variant in Ovarian Cancer Cases Clinically Negative for Pathogenic BRCA1 and BRCA2 Variants
(MDPI, 2022-04-15)Background: Detecting pathogenic intronic variants resulting in aberrant splicing remains a challenge in routine genetic testing. We describe germline whole-exome sequencing (WES) analyses and apply in silico predictive ... -
Cell-type specialization is encoded by specific chromatin topologies.
(2021-11)The three-dimensional (3D) structure of chromatin is intrinsically associated with gene regulation and cell function1-3. Methods based on chromatin conformation capture have mapped chromatin structures in neuronal systems ... -
Changes in STI and HIV testing and testing need among men who have sex with men during the UK's COVID-19 pandemic response.
(PMJ Publishing Group, 2023-05-17)OBJECTIVES: We examined the impact of COVID-19-related restrictions on sexual behaviours, STI and HIV testing and testing need among men who have sex with men (MSM) in the UK. METHODS: We used social media and dating ... -
Chickens get their place in the sun.
(BMC, 2007-05-25)A report on the International Chick Meeting 'The Chick as a Model Organism: Genes, Development and Function', Barcelona, Spain, 11-14 April 2007. -
Choice of antibiotics for prophylaxis of bacterial STIs among individuals currently self-sourcing.
(BMJ Publishing Group, 2021-12-06) -
Cluster algebras: Network science and machine learning
(Elsevier, 2023-12) -
Combinatorial ECM Arrays Identify Cooperative Roles for Matricellular Proteins in Enhancing the Generation of TH+ Neurons From Human Pluripotent Cells.
(2021)The development of efficient cell culture strategies for the generation of dopaminergic neurons is an important goal for transplantation-based approaches to treat Parkinson's disease. To identify extracellular matrix ... -
Comparative Investigation of the Microstructure of MgCl2 Aqueous Solutions Using Different X-ray Scattering Sources, Raman Spectroscopy, and Atomistic Simulations.
(2024-01-11)Aqueous solutions of magnesium chloride (MgCl2(aq)) are often used to test advances in the theory of electrolyte solutions because they are considered an ideal strong 2:1 electrolyte. However, there is evidence that some ...