dc.contributor.author | Woodfin, A | en_US |
dc.contributor.author | Voisin, MB | en_US |
dc.contributor.author | Beyrau, M | en_US |
dc.contributor.author | Colom, B | en_US |
dc.contributor.author | Caille, D | en_US |
dc.contributor.author | Diapouli, FM | en_US |
dc.contributor.author | Nash, GB | en_US |
dc.contributor.author | Chavakis, T | en_US |
dc.contributor.author | Albelda, SM | en_US |
dc.contributor.author | Rainger, GE | en_US |
dc.contributor.author | Meda, P | en_US |
dc.contributor.author | Imhof, BA | en_US |
dc.contributor.author | Nourshargh, S | en_US |
dc.date.accessioned | 2017-03-03T16:40:16Z | |
dc.date.available | 2011-05-26 | en_US |
dc.date.issued | 2011-08 | en_US |
dc.date.submitted | 2017-01-03T14:54:21.599Z | |
dc.identifier.issn | 1529-2908 | en_US |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/19663 | |
dc.description.abstract | The migration of neutrophils into inflamed tissues is a fundamental component of innate immunity. A decisive step in this process is the polarized migration of blood neutrophils through endothelial cells (ECs) lining the venular lumen (transendothelial migration (TEM)) in a luminal-to-abluminal direction. By real-time confocal imaging, we found that neutrophils had disrupted polarized TEM ('hesitant' and 'reverse') in vivo. We noted these events in inflammation after ischemia-reperfusion injury, characterized by lower expression of junctional adhesion molecule C (JAM-C) at EC junctions, and they were enhanced by blockade or genetic deletion of JAM-C in ECs. Our results identify JAM-C as a key regulator of polarized neutrophil TEM in vivo and suggest that reverse TEM of neutrophils can contribute to the dissemination of systemic inflammation. | |
dc.format.extent | 761 - U145 | en_US |
dc.relation.ispartof | NAT IMMUNOL | en_US |
dc.subject | GREEN FLUORESCENT PROTEIN | en_US |
dc.subject | TRANSCELLULAR MIGRATION | en_US |
dc.subject | LEUKOCYTE TRANSMIGRATION | en_US |
dc.subject | INFLAMMATION | en_US |
dc.subject | EXTRAVASATION | en_US |
dc.subject | PERMEABILITY | en_US |
dc.subject | ENDOTHELIUM | en_US |
dc.subject | RECRUITMENT | en_US |
dc.subject | INSERTION | en_US |
dc.subject | CONTACTS | en_US |
dc.title | The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo | en_US |
dc.type | Article | |
dc.rights.holder | © 2022 Springer Nature Limited | |
dc.identifier.doi | 10.1038/ni.2062 | en_US |
pubs.issue | 8 | en_US |
pubs.notes | Not known | en_US |
pubs.volume | 12 | en_US |
qmul.funder | An investigation into the molecular and cellular mechanisms involved in mediating neutrophil and monocyte transmigration in vivo::Wellcome Trust | en_US |