dc.contributor.author | Brentnall, AR | |
dc.contributor.author | Cuzick, J | |
dc.date.accessioned | 2016-11-08T09:08:49Z | |
dc.date.issued | 2016-11-08 | |
dc.date.issued | 2016-12-05 | |
dc.date.issued | 2016-01-01 | |
dc.date.submitted | 2016-10-31T10:40:12.507Z | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/16582 | |
dc.description.abstract | The concordance index is often used to measure how well a biomarker predicts the time to an event. Estimators of the concordance index for predictors of right-censored data are reviewed, including those based on censored pairs, inverse probability weighting and a proportional-hazards model. Predictive and prognostic biomarkers often lose strength with time, and in this case the aforementioned statistics depend on the length of follow up. A semi-parametric estimator of the concordance index is developed that accommodates converging hazards through a single parameter in a Pareto model. Concordance index estimators are assessed through simulations, which demonstrate substantial bias of classical censored-pairs and proportional-hazards model estimators. Prognostic biomarkers in a cohort of women diagnosed with breast cancer are evaluated using new and classical estimators of the concordance index. | |
dc.description.sponsorship | This work was funded by Cancer Research UK (grant number C569/A16891). | en_US |
dc.format.extent | 962280216680245 - ? | |
dc.language | eng | |
dc.language.iso | en | en_US |
dc.relation.ispartof | Stat Methods Med Res | |
dc.relation.isreplacedby | 123456789/18788 | |
dc.relation.isreplacedby | http://qmro.qmul.ac.uk/xmlui/handle/123456789/18788 | |
dc.subject | Biomarkers | |
dc.subject | C-index | |
dc.subject | Pareto model | |
dc.subject | discrimination | |
dc.subject | proportional-hazards model | |
dc.subject | survival analysis | |
dc.title | Use of the concordance index for predictors of censored survival data. | |
dc.type | Journal Article | |
dc.rights.holder | (c) The Authors, 2016 | |
dc.identifier.doi | 10.1177/0962280216680245 | |
dc.relation.isPartOf | Statistical Methods in Medical Research | |
dc.relation.isPartOf | Statistical Methods in Medical Research | |
dc.relation.isPartOf | Statistical Methods in Medical Research | |
pubs.author-url | http://www.ncbi.nlm.nih.gov/pubmed/27920368 | |
pubs.publication-status | Published online | |