Use of the concordance index for predictors of censored survival data.
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Embargoed until: 5555-01-01
Reason: Incorrect version
Embargoed until: 5555-01-01
Reason: Incorrect version
Pagination
962280216680245 - ?
DOI
10.1177/0962280216680245
Journal
Stat Methods Med Res
Metadata
Show full item recordAbstract
The concordance index is often used to measure how well a biomarker predicts the time to an event. Estimators of the concordance index for predictors of right-censored data are reviewed, including those based on censored pairs, inverse probability weighting and a proportional-hazards model. Predictive and prognostic biomarkers often lose strength with time, and in this case the aforementioned statistics depend on the length of follow up. A semi-parametric estimator of the concordance index is developed that accommodates converging hazards through a single parameter in a Pareto model. Concordance index estimators are assessed through simulations, which demonstrate substantial bias of classical censored-pairs and proportional-hazards model estimators. Prognostic biomarkers in a cohort of women diagnosed with breast cancer are evaluated using new and classical estimators of the concordance index.
Authors
Brentnall, AR; Cuzick, JCollections
- Centre for Cancer Prevention [1179]