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    The restorative role of annexin A1 at the blood-brain barrier. 
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    The restorative role of annexin A1 at the blood-brain barrier.

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    Published version (1.432Mb)
    Volume
    13
    Pagination
    17 - ?
    DOI
    10.1186/s12987-016-0043-0
    Journal
    Fluids Barriers CNS
    Issue
    1
    Metadata
    Show full item record
    Abstract
    Annexin A1 is a potent anti-inflammatory molecule that has been extensively studied in the peripheral immune system, but has not as yet been exploited as a therapeutic target/agent. In the last decade, we have undertaken the study of this molecule in the central nervous system (CNS), focusing particularly on the primary interface between the peripheral body and CNS: the blood-brain barrier. In this review, we provide an overview of the role of this molecule in the brain, with a particular emphasis on its functions in the endothelium of the blood-brain barrier, and the protective actions the molecule may exert in neuroinflammatory, neurovascular and metabolic disease. We focus on the possible new therapeutic avenues opened up by an increased understanding of the role of annexin A1 in the CNS vasculature, and its potential for repairing blood-brain barrier damage in disease and aging.
    Authors
    McArthur, S; Loiola, RA; Maggioli, E; Errede, M; Virgintino, D; Solito, E
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/16229
    Collections
    • Centre for Translational Medicine & Therapeutics [669]
    Language
    eng
    Licence information
    This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Creative Commons Attribution 4.0 International License
    Copyright statements
    © 2016 The Author(s)
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