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dc.contributor.authorAkbar, AN
dc.contributor.authorHenson, SM
dc.contributor.authorLanna, A
dc.date.accessioned2016-10-18T08:37:33Z
dc.date.issued2016-10-03
dc.date.issued2016-10-03
dc.date.issued2016-10-03
dc.date.issued2016-12
dc.date.issued2016-12
dc.date.submitted2016-09-09T16:46:03.826Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/15905
dc.description.abstractAs humans live longer, a central concern is to find ways to maintain their health as they age. Immunity declines during ageing, as shown by the increased susceptibility to infection by both previously encountered and new pathogens and by the decreased efficacy of vaccination. It is therefore crucial to understand the mechanisms responsible for this decrease in immunity and to develop new strategies to enhance immune function in older humans. We discuss here how the induction of senescence alters leukocyte, and specifically T cell, function. An emerging concept is that senescence and nutrient sensing-signalling pathways within T cells converge to regulate functional responses, and the manipulation of these pathways may offer new ways to enhance immunity during ageing.
dc.format.extent866 - 876
dc.languageeng
dc.language.isoenen_US
dc.relation.ispartofTrends Immunol
dc.rightsPublished online at http://www.cell.com/trends/immunology/fulltext/S1471-4906(16)30123-5#
dc.titleSenescence of T Lymphocytes: Implications for Enhancing Human Immunity.
dc.typeJournal Article
dc.rights.holder(c) The Authors, 2016
dc.identifier.doi10.1016/j.it.2016.09.002
dc.relation.isPartOfTrends in Immunology
dc.relation.isPartOfTrends in Immunology
dc.relation.isPartOfTrends Immunol
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/27720177
pubs.issue12
pubs.organisational-group/Queen Mary University of London
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/William Harvey Research Institute
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/William Harvey Research Institute/Microvascular Research
pubs.publication-statusPublished
pubs.volume37


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