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dc.contributor.authorLee, JWen_US
dc.contributor.authorMorris, JKen_US
dc.contributor.authorWALD, NJen_US
dc.contributor.editorAlpert, Jen_US
dc.date.accessioned2016-09-07T15:02:20Z
dc.date.available2016-06-14en_US
dc.date.submitted2016-08-11T10:16:49.657Z
dc.identifier.issn1555-7162en_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/15039
dc.descriptionThis is an invited letter - no abstract or keywords required
dc.descriptionThis is an invited letter - no abstract or keywords required
dc.descriptionThis is an invited letter - no abstract or keywords requireden_US
dc.description.abstractWe determined the validity of current medical advice to avoid grapefruit juice consumption while taking 3 widely used statins. A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260% if taken at the same time (about 90% if taken 12 hours apart), and atorvastatin by about 80% (whenever taken). Simvastatin 40 mg, lovastatin 40 mg, and atorvastatin 10 mg daily reduce low-density lipoprotein (LDL) cholesterol levels in a 60-year-old man with an LDL cholesterol of 4.8 mmol/L by 37%, reducing ischemic heart disease risk by 61%. When simvastatin or lovastatin are taken at the same time as grapefruit juice, the estimated reduction in LDL cholesterol is 48%, and in heart disease is 70%. If the juice is taken 12 hours before these statins, the reductions are, respectively, 43% and 66%, and for atorvastatin, 42% and 66%. The increased rhabdomyolysis risk from grapefruit juice consumption due to the increased effective statin dose is minimal compared with the greater effect in preventing heart disease. Grapefruit juice should not be contraindicated in people taking statins.en_US
dc.format.extent26 - 29 (4)en_US
dc.languageEnglishen_US
dc.publisherElsevieren_US
dc.relation.ispartofAmerican Journal of Medicineen_US
dc.rightshttp://dx.doi.org/10.1016/j.amjmed.2015.07.036
dc.subjectDrug interactionen_US
dc.subjectEffect enhanceren_US
dc.subjectGrapefruit juiceen_US
dc.subjectIschemic heart diseaseen_US
dc.subjectLDL cholesterolen_US
dc.subjectStatinsen_US
dc.titleGrapefruit Juice and Statins (Invited Letter in Response to Bailey)en_US
dc.typeArticle
dc.rights.holderCopyright © 2016 Elsevier Inc.
dc.identifier.doi10.1016/j.amjmed.2015.07.036.en_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.organisational-group/Queen Mary University of London
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/Wolfson Institute of Preventive Medicine
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/Wolfson Institute of Preventive Medicine/Environmental & Preventive Medicine
pubs.organisational-group/Queen Mary University of London/REF
pubs.organisational-group/Queen Mary University of London/REF/REF - Wolfson
pubs.publication-statusAccepteden_US
pubs.publisher-urlhttp://www.amjmed.com/article/S0002-9343(15)00774-3/fulltexten_US
pubs.volume129en_US
dcterms.dateAccepted2016-06-14en_US


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