dc.contributor.author | Sinha, AK | en_US |
dc.contributor.author | Murthy, V | en_US |
dc.contributor.author | Nath, P | en_US |
dc.contributor.author | Morris, JK | en_US |
dc.contributor.author | Millar, M | en_US |
dc.date.accessioned | 2016-07-07T12:52:21Z | |
dc.date.available | 2015-10-06 | en_US |
dc.date.issued | 2016-04 | en_US |
dc.date.submitted | 2016-06-28T14:46:19.499Z | |
dc.identifier.other | 10.1097/INF.0000000000001019 | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/13393 | |
dc.description.abstract | AIM: Late onset sepsis (LOS) and central-line associated blood stream infection (CLA-BSI) contribute toward the mortality and morbidity in prematurely born infants. The aim of this study is to investigate the effects of hospital-wide and unit-based interventions on LOS and CLA-BSI in infants born at <32 weeks gestation. METHODS: Intensive care, high dependency days and catheter days were obtained from the unit database and blood culture results from a microbiology laboratory database. Poisson regression was used to evaluate the effects of interventions on LOS and CLA-BSI. RESULTS: Quarterly rates of LOS reduced from 26.1 to 2.9 per 1000 intensive care, high dependency days and CLA-BSI from 31.6 to 4.3 per 1000 catheter days between 2007 and 2012. Appointment of a hospital specialist vascular device nurse, a change in the mode of administration of vancomycin, standardization of the hospital skin and hub disinfection policy and the introduction of a venous infusion phlebitis scoring system were associated with a reduction of LOS to 55% (95% confidence interval: 40-74%) and CLA-BSI 45% (95% confidence interval: 33-61%) of pre-intervention levels. The standardization of the neonatal unit policy for skin disinfection and a move to a new building were associated with reductions of LOS to 64% (47-87%) and 54% (34-88%), respectively, and aseptic no touch technique for infusion access with CLA-BSI to 53% (37-75%) of pre-intervention levels. CONCLUSION: A multifaceted approach involving changes in antimicrobial and skin disinfection policy, training for aseptic no touch technique and surveillance resulted in sustained reduction in LOS and CLA-BSI rates. | en_US |
dc.format.extent | 401 - 406 | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Pediatr Infect Dis J | en_US |
dc.subject | Bacteremia | en_US |
dc.subject | Catheter-Related Infections | en_US |
dc.subject | Central Venous Catheters | en_US |
dc.subject | Cross Infection | en_US |
dc.subject | Early Medical Intervention | en_US |
dc.subject | Humans | en_US |
dc.subject | Infant | en_US |
dc.subject | Infant, Newborn | en_US |
dc.subject | Seasons | en_US |
dc.subject | Sepsis | en_US |
dc.title | Prevention of Late Onset Sepsis and Central-line Associated Blood Stream Infection in Preterm Infants. | en_US |
dc.type | Article | |
dc.rights.holder | 2016 Wolters Kluwer Health, Inc. All rights reserved | |
dc.identifier.doi | 10.1097/INF.0000000000001019 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/26629870 | en_US |
pubs.issue | 4 | en_US |
pubs.notes | 12 months | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 35 | en_US |