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    The whole truth and nothing but the truth: the need for full reporting of randomised trials. 
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    • Centre for Translational Medicine & Therapeutics
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    The whole truth and nothing but the truth: the need for full reporting of randomised trials.

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    Published Version (334.3Kb)
    Volume
    4
    Pagination
    7 - ?
    DOI
    10.1186/s13741-015-0017-9
    Journal
    Perioper Med (Lond)
    ISSN
    2047-0525
    Metadata
    Show full item record
    Abstract
    The use of cardiac output monitoring to guide fluid and inotropic therapy in surgical patients has remained a controversial topic for more than 40 years. The reasons for this are numerous and complex, but key amongst them is the interplay between poor research methodology and the likely selective reporting of randomised trials. In this issue of Perioperative Medicine, we find a very unusual report, one which describes a randomised trial stopped for futility after the recruitment of only a small proportion of the target patient sample (Jammer et al. Periop Med). The authors offer no statistical analysis of their findings but simply an explanation of what went wrong. On the face of it, this exercise would seem to offer little of value to the general reader. How can publication of the findings of an unsuccessful trial contribute to the evidence base on this topic? To understand this, we must delve a little deeper into the evidence and see how these trials were designed.
    Authors
    Pearse, RM
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/11487
    Collections
    • Centre for Translational Medicine & Therapeutics [669]
    Language
    eng
    Licence information
    © Pearse. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​4.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.
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