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dc.contributor.authorManchanda, Ren_US
dc.contributor.authorJacobs, Ien_US
dc.date.accessioned2016-01-19T15:21:51Z
dc.date.issued2016-01en_US
dc.date.submitted2015-12-17T15:27:41.332Z
dc.identifier.other10.2217/fon.15.278
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/10784
dc.description.abstractThe landscape of cancer genetics in gynecological oncology is rapidly changing. The traditional family history-based approach has limitations and misses >50% mutation carriers. This is now being replaced by population-based approaches. The need for changing the clinical paradigm from family history-based to population-based BRCA1/BRCA2 testing in Ashkenazi Jews is supported by data that demonstrate population-based BRCA1/BRCA2 testing does not cause psychological harm and is cost effective. This article covers various genetic testing strategies for gynecological cancers, including population-based approaches, panel and direct-to-consumer testing as well as the need for innovative approaches to genetic counseling. Advances in genetic testing technology and computational analytics have facilitated an integrated systems medicine approach, providing increasing potential for population-based genetic testing, risk stratification, and cancer prevention. Genomic information along-with biological/computational tools will be used to deliver predictive, preventive, personalized and participatory (P4) and precision medicine in the future.en_US
dc.format.extent207 - 220en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofFuture Oncolen_US
dc.subjectBRCA1en_US
dc.subjectBRCA2en_US
dc.subjectcancer genesen_US
dc.subjectgenetic screeningen_US
dc.subjectgenetic testingen_US
dc.subjectpopulation screeningen_US
dc.subjectrisk predictionen_US
dc.subjectrisk stratificationen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectFemaleen_US
dc.subjectGenetic Counselingen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectGenetic Testingen_US
dc.subjectGenital Neoplasms, Femaleen_US
dc.subjectHumansen_US
dc.subjectJewsen_US
dc.subjectMass Screeningen_US
dc.subjectPopulation Surveillanceen_US
dc.subjectPrecision Medicineen_US
dc.subjectPrevalenceen_US
dc.subjectRisk Assessmenten_US
dc.subjectRisk Factorsen_US
dc.titleGenetic screening for gynecological cancer: where are we heading?en_US
dc.typeArticle
dc.rights.holderFuture Medicine Ltd
dc.identifier.doi10.2217/fon.15.278en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/26638726en_US
pubs.issue2en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume12en_US


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