Genetic dysbiosis: How host genetic variants may affect microbial biofilms
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Embargoed until: 5555-01-01
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Embargoed until: 5555-01-01
Reason: Version not permitted.
Pagination
431 - 441
ISBN-13
9781118982877
DOI
10.1002/9781118982907.ch28
Journal
The Human Microbiota and Chronic Disease: Dysbiosis as a Cause of Human Pathology
Metadata
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© 2016 by John Wiley & Sons, Inc. All rights reserved. A sensible hypothesis is that host genetic variants affect not only the individual ability to respond to microbial challenges, thus predisposing to the onset of acute microbial diseases, but also the normal composition of microbial biofilms, thus predisposing to a variation in the normal composition of microbial biofilms named "dysbiosis". This in turn could lead to what could be defined as "chronic microbial diseases", or diseases originated from the host response to a dysbiotic microbial biofilm. Recent evidence suggests that host genetic factors play a major role in deciding which bacteria colonize which host and in the composition of the natural human biofilms. Initial evidence has recently been produced for the effect of microbial recognition genes on microbial presence in periodontal and vaginal biofilms. A compelling example of how microbial recognition genes could affect the response to microbial challenge is given by the HIV.