Browsing Centre for Experimental Cancer Medicine by Title
Now showing items 1-20 of 130
-
The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer
(Impact journals, 2015-10-07)Patterns of glycosylation are important in cancer, but the molecular mechanisms that drive changes are often poorly understood. The androgen receptor drives prostate cancer (PCa) development and progression to lethal ... -
Androgen-dependent alternative mRNA isoform expression in prostate cancer cells.
(F1000Research, 2018-08-03)Background: Androgen steroid hormones are key drivers of prostate cancer. Previous work has shown that androgens can drive the expression of alternative mRNA isoforms as well as transcriptional changes in prostate cancer ... -
Attitude towards and factors affecting uptake of population based BRCA testing in the Ashkenazi Jewish population: a cohort study
(Wiley, 2019-02-15)Objective To evaluate factors affecting unselected‐population‐based‐BRCA‐testing in Ashkenazi‐Jews (AJ). Design Cohort‐study set within recruitment to the GCaPPS‐trial (ISRCTN73338115). Setting North‐London ... -
Benchmarking of surgical complications in gynaecological oncology: prospective multicentre study.
(2016-12)OBJECTIVE: To explore the impact of risk-adjustment on surgical complication rates (CRs) for benchmarking gynaecological oncology centres. DESIGN: Prospective cohort study. SETTING: Ten UK accredited gynaecological oncology ... -
Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis.
(BioMed Central, 2018-11-21)BACKGROUND: There are multiple existing and emerging therapeutic avenues for metastatic prostate cancer, with a common denominator, which is the need for predictive biomarkers. Circulating tumor DNA (ctDNA) has the potential ...