| dc.contributor.author | O'Shea, IP | en_US |
| dc.contributor.author | Shahed, M | en_US |
| dc.contributor.author | Aguilera-Venegas, B | en_US |
| dc.contributor.author | WILKINSON, SR | en_US |
| dc.date.accessioned | 2015-12-22T11:20:55Z | |
| dc.date.available | 2015-11-23 | en_US |
| dc.date.issued | 2016-02 | en_US |
| dc.date.submitted | 2015-11-24T14:00:09.316Z | |
| dc.identifier.issn | 1098-6596 | en_US |
| dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/10016 | |
| dc.description | OA Monitor Exercise | |
| dc.description | OA Monitor Exercise | en_US |
| dc.description.abstract | The growth inhibitory properties of a 5-nitrothiazole series was evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency towards the parasite while exhibiting little cytotoxic effect on mammalian cells, with this anti-parasitic activity being dependent on expression of a type I nitroreductase by the trypanosome. We conclude that the 5-nitrothiazole class of nitroheterocycle may represent new leads in the treatment of human African trypanosomiasis. | en_US |
| dc.description.sponsorship | BAV acknowledges financial support by FONDECYT Postdoctorado 3130364 | en_US |
| dc.format.extent | 1137 - 1140 (4) | en_US |
| dc.language | English | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | American Society for Microbiology | en_US |
| dc.relation.ispartof | Antimicrobial Agents and Chemotherapy | en_US |
| dc.rights | http://aac.asm.org/content/early/2015/11/17/AAC.02006-15.long doi: 10.1128/AAC.02006-15 | |
| dc.title | Evaluating 5-nitrothiazoles as trypanocidal agents | en_US |
| dc.type | Article | |
| dc.rights.holder | Copyright © 2016, American Society for Microbiology. | |
| dc.identifier.doi | 10.1128/AAC.02006-15 | en_US |
| pubs.issue | 2 | en_US |
| pubs.notes | Not known | en_US |
| pubs.publication-status | Accepted | en_US |
| pubs.publisher-url | http://aac.asm.org/content/60/2/1137.long | en_US |
| pubs.volume | 60 | en_US |
| dcterms.dateAccepted | 2015-11-23 | en_US |
