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    Evaluating 5-nitrothiazoles as trypanocidal agents 
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    Evaluating 5-nitrothiazoles as trypanocidal agents

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    Accepted version (706.8Kb)
    Volume
    60
    Pagination
    1137 - 1140 (4)
    Publisher
    American Society for Microbiology
    Publisher URL
    http://aac.asm.org/content/60/2/1137.long
    DOI
    10.1128/AAC.02006-15
    Journal
    Antimicrobial Agents and Chemotherapy
    Issue
    2
    ISSN
    1098-6596
    Metadata
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    Abstract
    The growth inhibitory properties of a 5-nitrothiazole series was evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency towards the parasite while exhibiting little cytotoxic effect on mammalian cells, with this anti-parasitic activity being dependent on expression of a type I nitroreductase by the trypanosome. We conclude that the 5-nitrothiazole class of nitroheterocycle may represent new leads in the treatment of human African trypanosomiasis.
    Authors
    O'Shea, IP; Shahed, M; Aguilera-Venegas, B; WILKINSON, SR
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/10016
    Collections
    • Centre for Genomics and Child Health [745]
    Language
    English
    Licence information
    http://aac.asm.org/content/early/2015/11/17/AAC.02006-15.long doi: 10.1128/AAC.02006-15
    Copyright statements
    Copyright © 2016, American Society for Microbiology.
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