Evaluating 5-nitrothiazoles as trypanocidal agents
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Volume
60
Pagination
1137 - 1140 (4)
Publisher
Publisher URL
DOI
10.1128/AAC.02006-15
Journal
Antimicrobial Agents and Chemotherapy
Issue
ISSN
1098-6596
Metadata
Show full item recordAbstract
The growth inhibitory properties of a 5-nitrothiazole series was evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency towards the parasite while exhibiting little cytotoxic effect on mammalian cells, with this anti-parasitic activity being dependent on expression of a type I nitroreductase by the trypanosome. We conclude that the 5-nitrothiazole class of nitroheterocycle may represent new leads in the treatment of human African trypanosomiasis.