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Now showing items 51-56 of 56
Linkage analysis of cross-sectional and longitudinally derived phenotypic measures to identify loci influencing blood pressure.
(2003-12-31)
BACKGROUND: The design of appropriate strategies to analyze and interpret linkage results for complex human diseases constitutes a challenge. Parameters such as power, definition of phenotype, and replicability have to be ...
Genetic and phenotypic effects of phonological short-term memory and grammatical morphology in specific language impairment.
(2008-06)
Deficits in phonological short-term memory and aspects of verb grammar morphology have been proposed as phenotypic markers of specific language impairment (SLI) with the suggestion that these traits are likely to be under ...
Familial loading in specific language impairment: patterns of differences across proband characteristics, gender and relative type.
(2007-04)
There is now little doubt that both environmental factors and genes are likely to make important contributions to the aetiology of specific language impairment (SLI). The most commonly proposed model for understanding these ...
Estimating intervention effects in a complex multi-level smoking prevention study.
(2009-02)
This paper illustrates how to estimate cumulative and non-cumulative treatment effects in a complex school-based smoking intervention study. The Instrumental Variable method is used to tackle non-compliance and measurement ...
The incidence of myocardial injury following post-operative Goal Directed Therapy.
(2007-03-19)
BACKGROUND: Studies suggest that Goal Directed Therapy (GDT) results in improved outcome following major surgery. However, there is concern that pre-emptive use of inotropic therapy may lead to an increased incidence of ...
A flexible model for multivariate interval-censored survival times with complex correlation structure.
(2007-02-10)
We focus on the analysis of multivariate survival times with highly structured interdependency and subject to interval censoring. Such data are common in developmental genetics and genetic epidemiology. We propose a flexible ...