Search
Now showing items 21-30 of 55
The impact of routine outcome measurement on treatment processes in community mental health care: approach and methods of the MECCA study.
(2002-07)
Three issues characterise the background to the MECCA study: A) Throughout Europe, most patients with severe forms of psychotic disorders are cared for in the community. The challenge now is to make processes in community ...
Identification of plasma protein biomarkers associated with idiopathic pulmonary arterial hypertension.
(2006-04)
We have employed SELDI-TOF MS to screen for differentially expressed proteins in plasma samples from 27 patients with idiopathic pulmonary arterial hypertension (IPAH) and 26 healthy controls. One ion (m/z approximately ...
Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis.
(2008-01)
Activated T cells require anti-apoptotic cytokines for their survival. The anti-apoptotic effects of these factors are mediated by their influence on the balance of expression and localisation of pro- and anti-apoptotic ...
Meeting report: national workshops for the communication of air pollution and health information: summary of four workshops in different regions of Europe.
(2006-07)
AIRNET was a thematic network project (2002-2004) initiated to stimulate the interaction between researchers in air pollution and health in Europe. As part of AIRNET's communication strategy, a standardized workshop model ...
Computer-based teaching is as good as face to face lecture-based teaching of evidence based medicine: a randomised controlled trial.
(2007-07-20)
BACKGROUND: At postgraduate level evidence based medicine (EBM) is currently taught through tutor based lectures. Computer based sessions fit around doctors' workloads, and standardise the quality of educational provision. ...
A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a.
(Public Library of Science, 2009-04-02)
The CDKN2A locus encodes two important tumor suppressors, INK4a and ARF, which respond to oncogenic stresses by inducing cellular senescence. We conducted a genome-scale cDNA overexpression screen using a reporter containing ...
Melanocortin peptide therapy for the treatment of arthritic pathologies.
(2009-12-16)
Arthritic pathologies are a major cause of morbidity within the western world, with rheumatoid arthritis affecting approximately 1% of adults. This review highlights the therapeutic potential of naturally occurring hormones ...
Molecular dissection of the human antibody response to the structural repeat epitope of Plasmodium falciparum sporozoite from a protected donor.
(2004-07-29)
BACKGROUND: The circumsporozoite surface protein is the primary target of human antibodies against Plasmodium falciparum sporozoites, these antibodies are predominantly directed to the major repetitive epitope (Asn-Pro-Asn-Ala)n, ...
Modelling multiple hospital outcomes: the impact of small area and primary care practice variation.
(2006-11-16)
BACKGROUND: Appropriate management of care--for example, avoiding unnecessary attendances at, or admissions to, hospital emergency units when they could be handled in primary care--is an important part of health strategy. ...
Production of hemo- and immunoregulatory cytokines by erythroblast antigen+ and glycophorin A+ cells from human bone marrow.
(2004-10-18)
BACKGROUND: Erythroid nuclear cells (ENC) of the bone marrow (BM) have not previously been considered as important producers of wide spectrum of haemo- and immunoregulatory cytokines. The aim of the current work was to ...
