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Now showing items 11-20 of 55
Identifying changes in selective constraints: host shifts in influenza.
(2009-11)
The natural reservoir of Influenza A is waterfowl. Normally, waterfowl viruses are not adapted to infect and spread in the human population. Sometimes, through reassortment or through whole host shift events, genetic ...
Preparation of alpha-synuclein fibrils for solid-state NMR: expression, purification, and incubation of wild-type and mutant forms.
(2006-07)
We report the expression and purification of alpha-synuclein, a protein implicated in Parkinson's disease, from isotopically (13C, 15N) labeled bacterial growth media, as required for solid-state NMR structural studies. ...
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
(2009-02)
OBJECTIVE: This study examined how differences in the BMI distribution of type 2 diabetic case subjects affected genome-wide patterns of type 2 diabetes association and considered the implications for the etiological ...
DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells.
(2007-12-31)
In addition to their well-known function in apoptosis, caspases are also important in several nonapoptotic processes. How caspase activity is restrained and shut down under such nonapoptotic conditions remains unknown. ...
In-vitro activity of polymyxin B in combination with imipenem, rifampicin and azithromycin versus multidrug resistant strains of Acinetobacter baumannii producing OXA-23 carbapenemases.
(2006-04-21)
BACKGROUND: Acinetobacter baumannii has emerged as a major nosocomial pathogen worldwide. Many of the circulating strains exhibit multi-drug resistance remaining consistently susceptible only to polymyxins. In-vitro studies ...
A systematic review of tests for lymph node status in primary endometrial cancer.
(2008-05-05)
BACKGROUND: The lymph node status of a patient is a key determinate in staging, prognosis and adjuvant treatment of endometrial cancer. Despite this, the potential additional morbidity associated with lymphadenectomy makes ...
Meta-DiSc: a software for meta-analysis of test accuracy data.
(2006-07-12)
BACKGROUND: Systematic reviews and meta-analyses of test accuracy studies are increasingly being recognised as central in guiding clinical practice. However, there is currently no dedicated and comprehensive software for ...
A comparison of the recording of 30 common childhood conditions in the Doctor's Independent Network and General Practice Research Databases.
(2004)
In this article we compare the recording of 30 common childhood conditions in two general practice databases of anonymised computerised medical records based on fundamentally different systems--the Doctor's Independent ...
Implications of the problem orientated medical record (POMR) for research using electronic GP databases: a comparison of the Doctors Independent Network Database (DIN) and the General Practice Research Database (GPRD).
(2003-09-30)
BACKGROUND: The General Practice Research Database (GPRD) and Doctor's Independent Network Database (DIN), are large electronic primary care databases compiled in the UK during the 1990s. They provide a valuable resource ...
Tests for predicting complications of pre-eclampsia: a protocol for systematic reviews.
(2008-08-11)
BACKGROUND: Pre-eclampsia is associated with several complications. Early prediction of complications and timely management is needed for clinical care of these patients to avert fetal and maternal mortality and morbidity. ...
