dc.contributor.author | Cacheiro, P | en_US |
dc.contributor.author | Smedley, D | en_US |
dc.date.accessioned | 2024-07-15T10:14:01Z | |
dc.date.available | 2023-02-17 | en_US |
dc.date.issued | 2023-09 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/98125 | |
dc.description.abstract | Protein coding genes exhibit different degrees of intolerance to loss-of-function variation. The most intolerant genes, whose function is essential for cell or/and organism survival, inform on fundamental biological processes related to cell proliferation and organism development and provide a window on the molecular mechanisms of human disease. Here we present a brief overview of the resources and knowledge gathered around gene essentiality, from cancer cell lines to model organisms to human development. We outline the implications of using different sources of evidence and definitions to determine which genes are essential and highlight how information on the essentiality status of a gene can inform novel disease gene discovery and therapeutic target identification. | en_US |
dc.format.extent | 357 - 363 | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Mamm Genome | en_US |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | |
dc.subject | Humans | en_US |
dc.subject | Genes, Essential | en_US |
dc.subject | Neoplasms | en_US |
dc.title | Essential genes: a cross-species perspective. | en_US |
dc.type | Article | |
dc.rights.holder | © The Author(s) 2023 | |
dc.identifier.doi | 10.1007/s00335-023-09984-1 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/36897351 | en_US |
pubs.issue | 3 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 34 | en_US |
dcterms.dateAccepted | 2023-02-17 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
qmul.funder | Mouse Phenotyping Informatics Infrastructure - Data acquisition, integration, analysis and translation of high throughput mammalian phenotyping data.::National Human Genome Research Institute | en_US |
rioxxterms.funder.project | b215eee3-195d-4c4f-a85d-169a4331c138 | en_US |