dc.contributor.author | Faheem, M | |
dc.contributor.author | Tam, HZ | |
dc.contributor.author | Nougom, M | |
dc.contributor.author | Suaris, T | |
dc.contributor.author | Jahan, N | |
dc.contributor.author | Lloyd, T | |
dc.contributor.author | Johnson, L | |
dc.contributor.author | Aggarwal, S | |
dc.contributor.author | Ullah, M | |
dc.contributor.author | Thompson, EW | |
dc.contributor.author | Brentnall, AR | |
dc.date.accessioned | 2024-07-12T08:16:27Z | |
dc.date.available | 2024-07-12T08:16:27Z | |
dc.date.issued | 2024-06-24 | |
dc.identifier.citation | Michael Faheem, Hui Zhen Tam, Magd Nougom, Tamara Suaris, Noor Jahan, Thomas Lloyd, Laura Johnson, Shweta Aggarwal, MdZaker Ullah, Erik W Thompson, Adam R Brentnall, Role of Supplemental Breast MRI in Screening Women with Mammographically Dense Breasts: A Systematic Review and Meta-analysis, Journal of Breast Imaging, 2024;, wbae019, https://doi.org/10.1093/jbi/wbae019 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/98054 | |
dc.description.abstract | BACKGROUND: High mammographic density increases breast cancer risk and reduces mammographic sensitivity. We reviewed evidence on accuracy of supplemental MRI for women with dense breasts at average or increased risk. METHODS: PubMed and Embase were searched 1995-2022. Articles were included if women received breast MRI following 2D or tomosynthesis mammography. Risk of bias was assessed using QUADAS-2. Analysis used independent studies from the articles. Fixed-effect meta-analytic summaries were estimated for predefined groups (PROSPERO: 230277). RESULTS: Eighteen primary research articles (24 studies) were identified in women aged 19-87 years. Breast density was heterogeneously or extremely dense (BI-RADS C/D) in 15/18 articles and extremely dense (BI-RADS D) in 3/18 articles. Twelve of 18 articles reported on increased-risk populations. Following 21 440 negative mammographic examinations, 288/320 cancers were detected by MRI. Substantial variation was observed between studies in MRI cancer detection rate, partly associated with prevalent vs incident MRI exams (prevalent: 16.6/1000 exams, 12 studies; incident: 6.8/1000 exams, 7 studies). MRI had high sensitivity for mammographically occult cancer (20 studies with at least 1-year follow-up). In 5/18 articles with sufficient data to estimate relative MRI detection rate, approximately 2 in 3 cancers were detected by MRI (66.3%, 95% CI, 56.3%-75.5%) but not mammography. Positive predictive value was higher for more recent studies. Risk of bias was low in most studies. CONCLUSION: Supplemental breast MRI following negative mammography in women with dense breasts has breast cancer detection rates of ~16.6/1000 at prevalent and ~6.8/1000 at incident MRI exams, considering both high and average risk settings. | en_US |
dc.language | eng | |
dc.publisher | Oxford University Press | en_US |
dc.relation.ispartof | J Breast Imaging | |
dc.subject | breast MRI | en_US |
dc.subject | breast cancer screening | en_US |
dc.subject | breast density | en_US |
dc.subject | mammographic density | en_US |
dc.subject | supplemental screening | en_US |
dc.title | Role of Supplemental Breast MRI in Screening Women with Mammographically Dense Breasts: A Systematic Review and Meta-analysis. | en_US |
dc.type | Article | en_US |
dc.rights.holder | © Society of Breast Imaging 2024. All rights reserved. | |
dc.identifier.doi | 10.1093/jbi/wbae019 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38912622 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
rioxxterms.funder.project | b215eee3-195d-4c4f-a85d-169a4331c138 | en_US |