dc.contributor.author | Nimmons, D | en_US |
dc.contributor.author | Aker, N | en_US |
dc.contributor.author | Burnand, A | en_US |
dc.contributor.author | Jordan, KP | en_US |
dc.contributor.author | Cooper, C | en_US |
dc.contributor.author | Davies, N | en_US |
dc.contributor.author | Manthorpe, J | en_US |
dc.contributor.author | Chew-Graham, CA | en_US |
dc.contributor.author | Kingstone, T | en_US |
dc.contributor.author | Petersen, I | en_US |
dc.contributor.author | Walters, K | en_US |
dc.date.accessioned | 2024-06-20T13:46:26Z | |
dc.date.available | 2023-12-06 | en_US |
dc.date.issued | 2024-02 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/97562 | |
dc.description.abstract | People living with dementia commonly experience anxiety, which is often challenging to manage. We investigated the effectiveness of treatments for the management of anxiety in this population. We conducted a systematic review and meta-analysis of randomised controlled trials, and searched EMBASE, CINAHL, MEDLINE and PsycInfo. We estimated standardised mean differences at follow-up between treatments relative to control groups and pooled these across studies using random-effects models where feasible. Thirty-one studies were identified. Meta-analysis demonstrated non-pharmacological interventions were effective in reducing anxiety in people living with dementia, compared to care as usual or active controls. Specifically, music therapy (SMD-1.92(CI:-2.58,-1.25)), muscular approaches (SMD-0.65(CI:-1.02,-0.28)) and stimulating cognitive and physical activities (SMD-0.31(CI:-0.53,-0.09)). Pharmacological interventions with evidence of potential effectiveness included Ginkgo biloba, probiotics, olanzapine, loxapine and citalopram compared to placebo, olanzapine compared to bromazepam and buspirone and risperidone compared to haloperidol. Meta-analyses were not performed for pharmacological interventions due to studies' heterogeneity. This has practice implications when promoting the use of more non-pharmacological interventions to help reduce anxiety among people living with dementia. | en_US |
dc.format.extent | 105507 - ? | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Neurosci Biobehav Rev | en_US |
dc.rights | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | |
dc.subject | Anxiety | en_US |
dc.subject | Dementia | en_US |
dc.subject | Treatment | en_US |
dc.subject | Humans | en_US |
dc.subject | Independent Living | en_US |
dc.subject | Olanzapine | en_US |
dc.subject | Anxiety | en_US |
dc.subject | Treatment Outcome | en_US |
dc.subject | Dementia | en_US |
dc.title | Clinical effectiveness of pharmacological and non-pharmacological treatments for the management of anxiety in community dwelling people living with dementia: A systematic review and meta-analysis. | en_US |
dc.type | Article | |
dc.rights.holder | © 2023 The Author(s). Published by Elsevier Ltd. | |
dc.identifier.doi | 10.1016/j.neubiorev.2023.105507 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38097097 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 157 | en_US |
dcterms.dateAccepted | 2023-12-06 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |