dc.contributor.author | Fokin, A | |
dc.contributor.author | Minderis, P | |
dc.contributor.author | Venckunas, T | |
dc.contributor.author | Lionikas, A | |
dc.contributor.author | Kvedaras, M | |
dc.contributor.author | Ratkevicius, A | |
dc.date.accessioned | 2024-05-28T09:40:15Z | |
dc.date.available | 2024-05-28T09:40:15Z | |
dc.date.issued | 2019-09-01 | |
dc.identifier.issn | 1108-7161 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/97074 | |
dc.description.abstract | OBJECTIVES: The aim of the study was to investigate if myostatin dysfunction can ameliorate fasting-induced muscle wasting. METHODS: 18-week old males from Berlin high (BEH) strain with myostatin dysfunction and wild type myostatin (BEH+/+) strain were subjected to 48-h food deprivation (FD). Changes in body composition as well as contractile properties of soleus (SOL) and extensor digitorum longus (EDL) muscles were studied. RESULTS: BEH mice were heavier than BEH+/+ mice (56.0±2.5 vs. 49.9±2.8 g, P<0.001, respectively). FD induced similar loss of body mass in BEH and BEH+/+ mice (16.6±2.4 vs. 17.4±2.2%, P>0.05), but only BEH mice experienced wasting of the gastrocnemius, tibialis anterior and plantaris muscles. FD induced a marked decrease in specific muscle force of SOL. EDL of BEH mice tended to be protected from this decline. CONCLUSION: Myostatin dysfunction does not protect from loss of muscle mass during fasting. | en_US |
dc.format.extent | 342 - 353 | |
dc.language | eng | |
dc.relation.ispartof | J Musculoskelet Neuronal Interact | |
dc.subject | Caloric Restriction | en_US |
dc.subject | Fasting | en_US |
dc.subject | Muscle Atrophy | en_US |
dc.subject | Muscle Specific Force | en_US |
dc.subject | Myostatin | en_US |
dc.subject | Animals | en_US |
dc.subject | Fasting | en_US |
dc.subject | Male | en_US |
dc.subject | Mice | en_US |
dc.subject | Mice, Mutant Strains | en_US |
dc.subject | Muscle, Skeletal | en_US |
dc.subject | Muscular Atrophy | en_US |
dc.subject | Myostatin | en_US |
dc.title | Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice. | en_US |
dc.type | Article | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/31475942 | en_US |
pubs.issue | 3 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 19 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |