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dc.contributor.authorSchilling, K
dc.contributor.authorChen, H
dc.contributor.authorGlabonjat, RA
dc.contributor.authorDebernardi, S
dc.contributor.authorBlyuss, O
dc.contributor.authorNavas-Acien, A
dc.contributor.authorHalliday, AN
dc.contributor.authorCrnogorac-Jurcevic, T
dc.date.accessioned2024-04-30T10:12:53Z
dc.date.available2024-04-30T10:12:53Z
dc.date.issued2024-04-02
dc.identifier.citationSchilling K, Chen H, Glabonjat RA, Debernardi S, Blyuss O, Navas-Acien A, Halliday AN and Crnogorac-Jurcevic T (2024) Analysis of urinary potassium isotopes and association with pancreatic health: healthy, diabetic and cancerous states. Front. Endocrinol. 15:1332895. doi: 10.3389/fendo.2024.1332895en_US
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/96532
dc.description.abstractBackground: More than 700 million people worldwide suffer from diseases of the pancreas, such as diabetes, pancreatitis and pancreatic cancer. Often dysregulation of potassium (K+) channels, co-transporters and pumps can promote development and progression of many types of these diseases. The role of K+ transport system in pancreatic cell homeostasis and disease development remains largely unexplored. Potassium isotope analysis (δ41K), however, might have the potential to detect minute changes in metabolic processes relevant for pancreatic diseases. Methods: We assessed urinary K isotope composition in a case-control study by measuring K concentrations and δ41K in spot urines collected from patients diagnosed with pancreatic cancer (n=18), other pancreas-related diseases (n=14) and compared those data to healthy controls (n=16). Results: Our results show that urinary K+ levels for patients with diseased pancreas (benign and pancreatic cancer) are significantly lower than the healthy controls. For δ41K, the values tend to be higher for individuals with pancreatic cancer (mean δ41K = -0.58 ± 0.33‰) than for healthy individuals (mean δ41K = -0.78 ± 0.19‰) but the difference is not significant (p=0.08). For diabetics, urinary K+ levels are significantly lower (p=0.03) and δ41K is significantly higher (p=0.009) than for the healthy controls. These results suggest that urinary K+ levels and K isotopes can help identify K disturbances related to diabetes, an associated factors of all-cause mortality for diabetics. Conclusion: Although the K isotope results should be considered exploratory and hypothesis-generating and future studies should focus on larger sample size and δ41K analysis of other K-disrupting diseases (e.g., chronic kidney disease), our data hold great promise for K isotopes as disease marker.en_US
dc.publisherFrontiers Mediaen_US
dc.relation.ispartofFrontiers in Endocrinology
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.titleAnalysis of urinary potassium isotopes and association with pancreatic health: healthy, diabetic and cancerous statesen_US
dc.typeArticleen_US
dc.rights.holder© 2024 Schilling, Chen, Glabonjat, Debernardi, Blyuss, Navas-Acien, Halliday and Crnogorac-Jurcevic.
dc.identifier.doi10.3389/fendo.2024.1332895
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume15en_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US


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