dc.contributor.author | Alao, J-P | |
dc.contributor.author | Legon, L | |
dc.contributor.author | Rallis, C | |
dc.date.accessioned | 2024-02-23T08:59:59Z | |
dc.date.available | 2021-01-28 | |
dc.date.available | 2024-02-23T08:59:59Z | |
dc.date.issued | 2021-02-02 | |
dc.identifier.citation | Alao, J.-P.; Legon, L.; Rallis, C. Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast. Cells 2021, 10, 305. https://doi.org/10.3390/cells10020305 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/94828 | |
dc.description.abstract | Cells have developed response systems to constantly monitor environmental changes and accordingly adjust growth, differentiation, and cellular stress programs. The evolutionarily conserved, nutrient-responsive, mechanistic target of rapamycin signaling (mTOR) pathway coordinates basic anabolic and catabolic cellular processes such as gene transcription, protein translation, autophagy, and metabolism, and is directly implicated in cellular and organismal aging as well as age-related diseases. mTOR mediates these processes in response to a broad range of inputs such as oxygen, amino acids, hormones, and energy levels, as well as stresses, including DNA damage. Here, we briefly summarize data relating to the interplays of the mTOR pathway with DNA damage response pathways in fission yeast, a favorite model in cell biology, and how these interactions shape cell decisions, growth, and cell-cycle progression. We, especially, comment on the roles of caffeine-mediated DNA-damage override. Understanding the biology of nutrient response, DNA damage and related pharmacological treatments can lead to the design of interventions towards improved cellular and organismal fitness, health, and survival. | en_US |
dc.language | eng | |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | Cells | |
dc.rights | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |
dc.subject | Rad3 | en_US |
dc.subject | TORC1 | en_US |
dc.subject | TORC2 | en_US |
dc.subject | caffeine | en_US |
dc.subject | nutrients | en_US |
dc.subject | rapamycin | en_US |
dc.subject | Gene Expression Regulation, Fungal | en_US |
dc.subject | Schizosaccharomyces | en_US |
dc.subject | Signal Transduction | en_US |
dc.subject | TOR Serine-Threonine Kinases | en_US |
dc.title | Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast. | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | |
dc.identifier.doi | 10.3390/cells10020305 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/33540829 | en_US |
pubs.issue | 2 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 10 | en_US |
dcterms.dateAccepted | 2021-01-28 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |