dc.contributor.author | Rallis, C | |
dc.contributor.author | Mülleder, M | |
dc.contributor.author | Smith, G | |
dc.contributor.author | Au, YZ | |
dc.contributor.author | Ralser, M | |
dc.contributor.author | Bähler, J | |
dc.date.accessioned | 2024-02-23T08:32:46Z | |
dc.date.available | 2024-02-23T08:32:46Z | |
dc.date.issued | 2020-11-03 | |
dc.identifier.citation | Charalampos Rallis, Michael Mülleder, Graeme Smith, Yan Zi Au, Markus Ralser, Jürg Bähler, Amino Acids Whose Intracellular Levels Change Most During Aging Alter Chronological Life Span of Fission Yeast, The Journals of Gerontology: Series A, Volume 76, Issue 2, February 2021, Pages 205–210, https://doi.org/10.1093/gerona/glaa246 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/94823 | |
dc.description.abstract | Amino acid deprivation or supplementation can affect cellular and organismal life span, but we know little about the role of concentration changes in free, intracellular amino acids during aging. Here, we determine free amino acid levels during chronological aging of nondividing fission yeast cells. We compare wild-type with long-lived mutant cells that lack the Pka1 protein of the protein kinase A signalling pathway. In wild-type cells, total amino acid levels decrease during aging, but much less so in pka1 mutants. Two amino acids strongly change as a function of age: glutamine decreases, especially in wild-type cells, while aspartate increases, especially in pka1 mutants. Supplementation of glutamine is sufficient to extend the chronological life span of wild-type but not of pka1Δ cells. Supplementation of aspartate, on the other hand, shortens the life span of pka1Δ but not of wild-type cells. Our results raise the possibility that certain amino acids are biomarkers of aging, and their concentrations during aging can promote or limit cellular life span. | en_US |
dc.format.extent | 205 - 210 | |
dc.language | eng | |
dc.publisher | Oxford University Press | en_US |
dc.relation.ispartof | J Gerontol A Biol Sci Med Sci | |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | |
dc.subject | S pombe | en_US |
dc.subject | aspartate | en_US |
dc.subject | glutamine | en_US |
dc.subject | metabolome | en_US |
dc.subject | protein kinase A | en_US |
dc.subject | Amino Acids | en_US |
dc.subject | Aspartic Acid | en_US |
dc.subject | Cyclic AMP-Dependent Protein Kinases | en_US |
dc.subject | Glutamine | en_US |
dc.subject | Mutation | en_US |
dc.subject | Schizosaccharomyces | en_US |
dc.subject | Schizosaccharomyces pombe Proteins | en_US |
dc.subject | Signal Transduction | en_US |
dc.title | Amino Acids Whose Intracellular Levels Change Most During Aging Alter Chronological Life Span of Fission Yeast. | en_US |
dc.type | Article | en_US |
dc.rights.holder | © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. | |
dc.identifier.doi | 10.1093/gerona/glaa246 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/32991693 | en_US |
pubs.issue | 2 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 76 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |