dc.contributor.author | Gal, C | |
dc.contributor.author | Cochrane, GA | |
dc.contributor.author | Morgan, BA | |
dc.contributor.author | Rallis, C | |
dc.contributor.author | Bahler, J | |
dc.contributor.author | Whitehall, SK | |
dc.date.accessioned | 2024-02-23T08:24:09Z | |
dc.date.available | 2024-02-23T08:24:09Z | |
dc.date.issued | 2023-08-27 | |
dc.identifier.citation | Csenge Gal, Grace A. Cochrane, Brian A. Morgan, Charalampos Rallis, Jürg Bähler & Simon K. Whitehall (2023) The longevity and reversibility of quiescence in Schizosaccharomyces pombe are dependent upon the HIRA histone chaperone, Cell Cycle, 22:17, 1921-1936, DOI: 10.1080/15384101.2023.2249705 | |
dc.identifier.issn | 1538-4101 | |
dc.identifier.other | ARTN 2249705 | |
dc.identifier.other | ARTN 2249705 | |
dc.identifier.other | ARTN 2249705 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/94821 | |
dc.description.abstract | Quiescence (G0) is a reversible non-dividing state that facilitates cellular survival in adverse conditions. Here, we demonstrate that the HIRA histone chaperone complex is required for the reversibility and longevity of nitrogen starvation-induced quiescence in Schizosaccharomyces pombe. The HIRA protein, Hip1 is not required for entry into G0 or the induction of autophagy. Although hip1Δ cells retain metabolic activity in G0, they rapidly lose the ability to resume proliferation. After a short period in G0 (1 day), hip1Δ mutants can resume cell growth in response to the restoration of a nitrogen source but do not efficiently reenter the vegetative cell cycle. This correlates with a failure to induce the expression of MBF transcription factor-dependent genes that are critical for S phase. In addition, hip1Δ G0 cells rapidly progress to a senescent state in which they can no longer re-initiate growth following nitrogen source restoration. Analysis of a conditional hip1 allele is consistent with these findings and indicates that HIRA is required for efficient exit from quiescence and prevents an irreversible cell cycle arrest. | en_US |
dc.publisher | Taylor and Francis Group | en_US |
dc.relation.ispartof | CELL CYCLE | |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent | |
dc.rights | © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. | |
dc.subject | HIRA | en_US |
dc.subject | histone chaperone | en_US |
dc.subject | quiescence | en_US |
dc.subject | G0 | en_US |
dc.subject | MBF transcription factor | en_US |
dc.subject | chromatin | en_US |
dc.title | The longevity and reversibility of quiescence in Schizosaccharomyces pombe are dependent upon the HIRA histone chaperone | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. | |
dc.identifier.doi | 10.1080/15384101.2023.2249705 | |
pubs.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:001056954300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6a | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |