dc.contributor.author | Hill, H | |
dc.contributor.author | Kearns, B | |
dc.contributor.author | Pashayan, N | |
dc.contributor.author | Roadevin, C | |
dc.contributor.author | Sasieni, P | |
dc.contributor.author | Offman, J | |
dc.contributor.author | Duffy, S | |
dc.date.accessioned | 2024-01-09T15:45:34Z | |
dc.date.available | 2023-10-04 | |
dc.date.available | 2024-01-09T15:45:34Z | |
dc.date.issued | 2023-11 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/93681 | |
dc.description.abstract | BACKGROUND: There has been growing interest in the UK and internationally of risk-stratified breast screening whereby individualised risk assessment may inform screening frequency, starting age, screening instrument used, or even decisions not to screen. This study evaluates the cost-effectiveness of eight proposals for risk-stratified screening regimens compared to both the current UK screening programme and no national screening. METHODS: A person-level microsimulation model was developed to estimate health-related quality of life, cancer survival and NHS costs over the lifetime of the female population eligible for screening in the UK. RESULTS: Compared with both the current screening programme and no screening, risk-stratified regimens generated additional costs and QALYs, and had a larger net health benefit. The likelihood of the current screening programme being the optimal scenario was less than 1%. No screening amongst the lowest risk group, and triannual, biennial and annual screening amongst the three higher risk groups was the optimal screening strategy from those evaluated. CONCLUSIONS: We found that risk-stratified breast cancer screening has the potential to be beneficial for women at the population level, but the net health benefit will depend on the particular risk-based strategy. | en_US |
dc.format.extent | 1801 - 1809 | |
dc.language | eng | |
dc.relation.ispartof | Br J Cancer | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | Humans | en_US |
dc.subject | Female | en_US |
dc.subject | Breast Neoplasms | en_US |
dc.subject | Cost-Benefit Analysis | en_US |
dc.subject | Quality of Life | en_US |
dc.subject | Early Detection of Cancer | en_US |
dc.subject | Risk Factors | en_US |
dc.subject | Mass Screening | en_US |
dc.subject | Quality-Adjusted Life Years | en_US |
dc.subject | United Kingdom | en_US |
dc.title | The cost-effectiveness of risk-stratified breast cancer screening in the UK. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/s41416-023-02461-1 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/37848734 | en_US |
pubs.issue | 11 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 129 | en_US |
dcterms.dateAccepted | 2023-10-04 | |