Show simple item record

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

dc.contributor.authorWang, A
dc.contributor.authorShen, J
dc.contributor.authorRodriguez, AA
dc.contributor.authorSaunders, EJ
dc.contributor.authorChen, F
dc.contributor.authorJanivara, R
dc.contributor.authorDarst, BF
dc.contributor.authorSheng, X
dc.contributor.authorXu, Y
dc.contributor.authorChou, AJ
dc.contributor.authorBenlloch, S
dc.contributor.authorDadaev, T
dc.contributor.authorBrook, MN
dc.contributor.authorPlym, A
dc.contributor.authorSahimi, A
dc.contributor.authorHoffman, TJ
dc.contributor.authorTakahashi, A
dc.contributor.authorMatsuda, K
dc.contributor.authorMomozawa, Y
dc.contributor.authorFujita, M
dc.contributor.authorLaisk, T
dc.contributor.authorFiguerêdo, J
dc.contributor.authorMuir, K
dc.contributor.authorIto, S
dc.contributor.authorLiu, X
dc.contributor.authorBiobank Japan Project
dc.contributor.authorUchio, Y
dc.contributor.authorKubo, M
dc.contributor.authorKamatani, Y
dc.contributor.authorLophatananon, A
dc.contributor.authorWan, P
dc.contributor.authorAndrews, C
dc.contributor.authorLori, A
dc.contributor.authorChoudhury, PP
dc.contributor.authorSchleutker, J
dc.contributor.authorTammela, TLJ
dc.contributor.authorSipeky, C
dc.contributor.authorAuvinen, A
dc.contributor.authorGiles, GG
dc.contributor.authorSouthey, MC
dc.contributor.authorMacInnis, RJ
dc.contributor.authorCybulski, C
dc.contributor.authorWokolorczyk, D
dc.contributor.authorLubinski, J
dc.contributor.authorRentsch, CT
dc.contributor.authorCho, K
dc.contributor.authorMcmahon, BH
dc.contributor.authorNeal, DE
dc.contributor.authorDonovan, JL
dc.contributor.authorHamdy, FC
dc.contributor.authorMartin, RM
dc.contributor.authorNordestgaard, BG
dc.contributor.authorNielsen, SF
dc.contributor.authorWeischer, M
dc.contributor.authorBojesen, SE
dc.contributor.authorRøder, A
dc.contributor.authorStroomberg, HV
dc.contributor.authorBatra, J
dc.contributor.authorChambers, S
dc.contributor.authorHorvath, L
dc.contributor.authorClements, JA
dc.contributor.authorTilly, W
dc.contributor.authorRisbridger, GP
dc.contributor.authorGronberg, H
dc.contributor.authorAly, M
dc.contributor.authorSzulkin, R
dc.contributor.authorEklund, M
dc.contributor.authorNordstrom, T
dc.contributor.authorPashayan, N
dc.contributor.authorDunning, AM
dc.contributor.authorGhoussaini, M
dc.contributor.authorTravis, RC
dc.contributor.authorKey, TJ
dc.contributor.authorRiboli, E
dc.contributor.authorPark, JY
dc.contributor.authorSellers, TA
dc.contributor.authorLin, H-Y
dc.contributor.authorAlbanes, D
dc.contributor.authorWeinstein, S
dc.contributor.authorCook, MB
dc.contributor.authorMucci, LA
dc.contributor.authorGiovannucci, E
dc.contributor.authorLindstrom, S
dc.contributor.authorKraft, P
dc.contributor.authorHunter, DJ
dc.contributor.authorPenney, KL
dc.contributor.authorTurman, C
dc.contributor.authorTangen, CM
dc.contributor.authorGoodman, PJ
dc.contributor.authorThompson, IM
dc.contributor.authorHamilton, RJ
dc.contributor.authorFleshner, NE
dc.contributor.authorFinelli, A
dc.contributor.authorParent, M-É
dc.contributor.authorStanford, JL
dc.contributor.authorOstrander, EA
dc.contributor.authorKoutros, S
dc.contributor.authorBeane Freeman, LE
dc.contributor.authorStampfer, M
dc.contributor.authorWolk, A
dc.contributor.authorHåkansson, N
dc.contributor.authorAndriole, GL
dc.contributor.authorHoover, RN
dc.contributor.authorMachiela, MJ
dc.contributor.authorSørensen, KD
dc.contributor.authorBorre, M
dc.contributor.authorBlot, WJ
dc.contributor.authorZheng, W
dc.contributor.authorYeboah, ED
dc.contributor.authorMensah, JE
dc.contributor.authorLu, Y-J
dc.contributor.authorZhang, H-W
dc.contributor.authorFeng, N
dc.contributor.authorMao, X
dc.contributor.authorWu, Y
dc.contributor.authorZhao, S-C
dc.contributor.authorSun, Z
dc.contributor.authorThibodeau, SN
dc.contributor.authorMcDonnell, SK
dc.contributor.authorSchaid, DJ
dc.contributor.authorWest, CML
dc.contributor.authorBarnett, G
dc.contributor.authorMaier, C
dc.contributor.authorSchnoeller, T
dc.contributor.authorLuedeke, M
dc.contributor.authorKibel, AS
dc.contributor.authorDrake, BF
dc.contributor.authorCussenot, O
dc.contributor.authorCancel-Tassin, G
dc.contributor.authorMenegaux, F
dc.contributor.authorTruong, T
dc.contributor.authorKoudou, YA
dc.contributor.authorJohn, EM
dc.contributor.authorGrindedal, EM
dc.contributor.authorMaehle, L
dc.contributor.authorKhaw, K-T
dc.contributor.authorIngles, SA
dc.contributor.authorStern, MC
dc.contributor.authorVega, A
dc.contributor.authorGómez-Caamaño, A
dc.contributor.authorFachal, L
dc.contributor.authorRosenstein, BS
dc.contributor.authorKerns, SL
dc.contributor.authorOstrer, H
dc.contributor.authorTeixeira, MR
dc.contributor.authorPaulo, P
dc.contributor.authorBrandão, A
dc.contributor.authorWatya, S
dc.contributor.authorLubwama, A
dc.contributor.authorBensen, JT
dc.contributor.authorButler, EN
dc.contributor.authorMohler, JL
dc.contributor.authorTaylor, JA
dc.contributor.authorKogevinas, M
dc.contributor.authorDierssen-Sotos, T
dc.contributor.authorCastaño-Vinyals, G
dc.contributor.authorCannon-Albright, L
dc.contributor.authorTeerlink, CC
dc.contributor.authorHuff, CD
dc.contributor.authorPilie, P
dc.contributor.authorYu, Y
dc.contributor.authorBohlender, RJ
dc.contributor.authorGu, J
dc.contributor.authorStrom, SS
dc.contributor.authorMultigner, L
dc.contributor.authorBlanchet, P
dc.contributor.authorBrureau, L
dc.contributor.authorKaneva, R
dc.contributor.authorSlavov, C
dc.contributor.authorMitev, V
dc.contributor.authorLeach, RJ
dc.contributor.authorBrenner, H
dc.contributor.authorChen, X
dc.contributor.authorHolleczek, B
dc.contributor.authorSchöttker, B
dc.contributor.authorKlein, EA
dc.contributor.authorHsing, AW
dc.contributor.authorKittles, RA
dc.contributor.authorMurphy, AB
dc.contributor.authorLogothetis, CJ
dc.contributor.authorKim, J
dc.contributor.authorNeuhausen, SL
dc.contributor.authorSteele, L
dc.contributor.authorDing, YC
dc.contributor.authorIsaacs, WB
dc.contributor.authorNemesure, B
dc.contributor.authorHennis, AJM
dc.contributor.authorCarpten, J
dc.contributor.authorPandha, H
dc.contributor.authorMichael, A
dc.contributor.authorDe Ruyck, K
dc.contributor.authorDe Meerleer, G
dc.contributor.authorOst, P
dc.contributor.authorXu, J
dc.contributor.authorRazack, A
dc.contributor.authorLim, J
dc.contributor.authorTeo, S-H
dc.contributor.authorNewcomb, LF
dc.contributor.authorLin, DW
dc.contributor.authorFowke, JH
dc.contributor.authorNeslund-Dudas, CM
dc.contributor.authorRybicki, BA
dc.contributor.authorGamulin, M
dc.contributor.authorLessel, D
dc.contributor.authorKulis, T
dc.contributor.authorUsmani, N
dc.contributor.authorAbraham, A
dc.contributor.authorSinghal, S
dc.contributor.authorParliament, M
dc.contributor.authorClaessens, F
dc.contributor.authorJoniau, S
dc.contributor.authorVan den Broeck, T
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorCastelao, JE
dc.contributor.authorMartinez, ME
dc.contributor.authorLarkin, S
dc.contributor.authorTownsend, PA
dc.contributor.authorAukim-Hastie, C
dc.contributor.authorBush, WS
dc.contributor.authorAldrich, MC
dc.contributor.authorCrawford, DC
dc.contributor.authorSrivastava, S
dc.contributor.authorCullen, J
dc.contributor.authorPetrovics, G
dc.contributor.authorCasey, G
dc.contributor.authorWang, Y
dc.contributor.authorTettey, Y
dc.contributor.authorLachance, J
dc.contributor.authorTang, W
dc.contributor.authorBiritwum, RB
dc.contributor.authorAdjei, AA
dc.contributor.authorTay, E
dc.contributor.authorTruelove, A
dc.contributor.authorNiwa, S
dc.contributor.authorYamoah, K
dc.contributor.authorGovindasami, K
dc.contributor.authorChokkalingam, AP
dc.contributor.authorKeaton, JM
dc.contributor.authorHellwege, JN
dc.contributor.authorClark, PE
dc.contributor.authorJalloh, M
dc.contributor.authorGueye, SM
dc.contributor.authorNiang, L
dc.contributor.authorOgunbiyi, O
dc.contributor.authorShittu, O
dc.contributor.authorAmodu, O
dc.contributor.authorAdebiyi, AO
dc.contributor.authorAisuodionoe-Shadrach, OI
dc.contributor.authorAjibola, HO
dc.contributor.authorJamda, MA
dc.contributor.authorOluwole, OP
dc.contributor.authorNwegbu, M
dc.contributor.authorAdusei, B
dc.contributor.authorMante, S
dc.contributor.authorDarkwa-Abrahams, A
dc.contributor.authorDiop, H
dc.contributor.authorGundell, SM
dc.contributor.authorRoobol, MJ
dc.contributor.authorJenster, G
dc.contributor.authorvan Schaik, RHN
dc.contributor.authorHu, JJ
dc.contributor.authorSanderson, M
dc.contributor.authorKachuri, L
dc.contributor.authorVarma, R
dc.contributor.authorMcKean-Cowdin, R
dc.contributor.authorTorres, M
dc.contributor.authorPreuss, MH
dc.contributor.authorLoos, RJF
dc.contributor.authorZawistowski, M
dc.contributor.authorZöllner, S
dc.contributor.authorLu, Z
dc.contributor.authorVan Den Eeden, SK
dc.contributor.authorEaston, DF
dc.contributor.authorAmbs, S
dc.contributor.authorEdwards, TL
dc.contributor.authorMägi, R
dc.contributor.authorRebbeck, TR
dc.contributor.authorFritsche, L
dc.contributor.authorChanock, SJ
dc.contributor.authorBerndt, SI
dc.contributor.authorWiklund, F
dc.contributor.authorNakagawa, H
dc.contributor.authorWitte, JS
dc.contributor.authorGaziano, JM
dc.contributor.authorJustice, AC
dc.contributor.authorMancuso, N
dc.contributor.authorTerao, C
dc.contributor.authorEeles, RA
dc.contributor.authorKote-Jarai, Z
dc.contributor.authorMadduri, RK
dc.contributor.authorConti, DV
dc.contributor.authorHaiman, CA
dc.date.accessioned2024-01-08T14:12:10Z
dc.date.available2023-09-15
dc.date.available2024-01-08T14:12:10Z
dc.date.issued2023-11-09
dc.identifier.citationWang, A., Shen, J., Rodriguez, A.A. et al. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. Nat Genet 55, 2065–2074 (2023). https://doi.org/10.1038/s41588-023-01534-4
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/93551
dc.description.abstractThe transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.en_US
dc.format.extent2065 - 2074
dc.languageeng
dc.publisherNature Researchen_US
dc.relation.ispartofNat Genet
dc.titleCharacterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variantsen_US
dc.typeArticleen_US
dc.rights.holderThis version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41588-023-01534-4
dc.identifier.doi10.1038/s41588-023-01534-4
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37945903en_US
pubs.issue12en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume55en_US
dcterms.dateAccepted2023-09-15
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US


Files in this item

Thumbnail
Name:
Characterizing prostate cancer ...
Size:
1.402Mb
Format:
application/
Description:
Accepted Version
View/Open

This item appears in the following Collection(s)

Show simple item record