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dc.contributor.authorSobocan, M
dc.contributor.authorChandrasekaran, D
dc.contributor.authorSideris, M
dc.contributor.authorBlyuss, O
dc.contributor.authorFierheller, C
dc.contributor.authorKalra, A
dc.contributor.authorSia, J
dc.contributor.authorMiller, RE
dc.contributor.authorMills-Baldock, T
dc.contributor.authorCrusz, SM
dc.contributor.authorSun, L
dc.contributor.authorEvans, O
dc.contributor.authorRobbani, S
dc.contributor.authorJenkins, LA
dc.contributor.authorAhmed, M
dc.contributor.authorKumar, A
dc.contributor.authorQuigley, M
dc.contributor.authorLockley, M
dc.contributor.authorFaruqi, A
dc.contributor.authorCasey, L
dc.contributor.authorBrockbank, E
dc.contributor.authorPhadnis, S
dc.contributor.authorTrevisan, G
dc.contributor.authorSingh, N
dc.contributor.authorLegood, R
dc.contributor.authorManchanda, R
dc.date.accessioned2023-10-25T10:38:14Z
dc.date.available2023-09-05
dc.date.available2023-10-25T10:38:14Z
dc.date.issued2023-09-26
dc.identifier.issn1471-0528
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/91563
dc.description.abstractOBJECTIVE: To evaluate patient preference for short (gist) or detailed/extensive decision aids (DA) for genetic testing at ovarian cancer (OC) diagnosis. DESIGN: Cohort study set within recruitment to the Systematic Genetic Testing for Personalised Ovarian Cancer Therapy (SIGNPOST) study (ISRCTN: 16988857). SETTING: North-East London Cancer Network (NELCN) population. POPULATION/SAMPLE: Women with high-grade non-mucinous epithelial OC. METHODS: A more detailed DA was developed using patient and stakeholder input following the principles/methodology of IPDAS (International Patients Decision Aids Standards). Unselected patients attending oncology clinics evaluated both a pre-existing short and a new long DA version and then underwent mainstreaming genetic testing by a cancer clinician. Appropriate inferential descriptive and regression analyses were undertaken. MAIN OUTCOME MEASURES: Satisfaction, readability, understanding, emotional well-being and preference for long/short DA. RESULTS: The mean age of patients was 66 years (interquartile range 11), and 85% were White British ethnicity. Of the participants, 74% found DAs helpful/useful in decision-making. Women reported higher levels of satisfaction (86% versus 58%, p < 0.001), right amount of information provided (76.79% versus49.12%, p < 0.001) and improved understanding (p < 0.001) with the long DA compared with the short DA. There was no statistically significant difference in emotional outcomes (feeling worried/concerned/reassured/upset) between 'short' and 'long' DA; 74% of patients preferred the long DA and 24% the short DA. Patients undergoing treatment (correlation coefficient (coef) = 0.603; 95% CI 0.165-1.041, p = 0.007), those with recurrence (coef = 0.493; 95% CI 0.065-0.92, p = 0.024) and older women (coef = 0.042; 95% CI 0.017-0.066, p = 0.001) preferred the short DA. Ethnicity did not affect outcomes or overall preference for long/short DA. CONCLUSIONS: A longer DA in OC patients has higher satisfaction without increasing emotional distress. Older women and those undergoing treatment/recurrence prefer less extensive information, whereas those in remission preferred a longer DA.en_US
dc.languageeng
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofBJOG: An International Journal of Obstetrics and Gynaecology
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
dc.subjectDecision aidsen_US
dc.subjectgenetic testingen_US
dc.subjectmainstreamingen_US
dc.subjectovarian canceren_US
dc.titlePatient decision aids in mainstreaming genetic testing for women with ovarian cancer: A prospective cohort study.en_US
dc.typeArticleen_US
dc.rights.holder© 2023 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.
dc.identifier.doi10.1111/1471-0528.17675
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37752678en_US
pubs.notesNot knownen_US
pubs.publication-statusPublished onlineen_US
dcterms.dateAccepted2023-09-05
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US


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