dc.contributor.author | Sobocan, M | |
dc.contributor.author | Chandrasekaran, D | |
dc.contributor.author | Sideris, M | |
dc.contributor.author | Blyuss, O | |
dc.contributor.author | Fierheller, C | |
dc.contributor.author | Kalra, A | |
dc.contributor.author | Sia, J | |
dc.contributor.author | Miller, RE | |
dc.contributor.author | Mills-Baldock, T | |
dc.contributor.author | Crusz, SM | |
dc.contributor.author | Sun, L | |
dc.contributor.author | Evans, O | |
dc.contributor.author | Robbani, S | |
dc.contributor.author | Jenkins, LA | |
dc.contributor.author | Ahmed, M | |
dc.contributor.author | Kumar, A | |
dc.contributor.author | Quigley, M | |
dc.contributor.author | Lockley, M | |
dc.contributor.author | Faruqi, A | |
dc.contributor.author | Casey, L | |
dc.contributor.author | Brockbank, E | |
dc.contributor.author | Phadnis, S | |
dc.contributor.author | Trevisan, G | |
dc.contributor.author | Singh, N | |
dc.contributor.author | Legood, R | |
dc.contributor.author | Manchanda, R | |
dc.date.accessioned | 2023-10-25T10:38:14Z | |
dc.date.available | 2023-09-05 | |
dc.date.available | 2023-10-25T10:38:14Z | |
dc.date.issued | 2023-09-26 | |
dc.identifier.issn | 1471-0528 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/91563 | |
dc.description.abstract | OBJECTIVE: To evaluate patient preference for short (gist) or detailed/extensive decision aids (DA) for genetic testing at ovarian cancer (OC) diagnosis. DESIGN: Cohort study set within recruitment to the Systematic Genetic Testing for Personalised Ovarian Cancer Therapy (SIGNPOST) study (ISRCTN: 16988857). SETTING: North-East London Cancer Network (NELCN) population. POPULATION/SAMPLE: Women with high-grade non-mucinous epithelial OC. METHODS: A more detailed DA was developed using patient and stakeholder input following the principles/methodology of IPDAS (International Patients Decision Aids Standards). Unselected patients attending oncology clinics evaluated both a pre-existing short and a new long DA version and then underwent mainstreaming genetic testing by a cancer clinician. Appropriate inferential descriptive and regression analyses were undertaken. MAIN OUTCOME MEASURES: Satisfaction, readability, understanding, emotional well-being and preference for long/short DA. RESULTS: The mean age of patients was 66 years (interquartile range 11), and 85% were White British ethnicity. Of the participants, 74% found DAs helpful/useful in decision-making. Women reported higher levels of satisfaction (86% versus 58%, p < 0.001), right amount of information provided (76.79% versus49.12%, p < 0.001) and improved understanding (p < 0.001) with the long DA compared with the short DA. There was no statistically significant difference in emotional outcomes (feeling worried/concerned/reassured/upset) between 'short' and 'long' DA; 74% of patients preferred the long DA and 24% the short DA. Patients undergoing treatment (correlation coefficient (coef) = 0.603; 95% CI 0.165-1.041, p = 0.007), those with recurrence (coef = 0.493; 95% CI 0.065-0.92, p = 0.024) and older women (coef = 0.042; 95% CI 0.017-0.066, p = 0.001) preferred the short DA. Ethnicity did not affect outcomes or overall preference for long/short DA. CONCLUSIONS: A longer DA in OC patients has higher satisfaction without increasing emotional distress. Older women and those undergoing treatment/recurrence prefer less extensive information, whereas those in remission preferred a longer DA. | en_US |
dc.language | eng | |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.ispartof | BJOG: An International Journal of Obstetrics and Gynaecology | |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | |
dc.subject | Decision aids | en_US |
dc.subject | genetic testing | en_US |
dc.subject | mainstreaming | en_US |
dc.subject | ovarian cancer | en_US |
dc.title | Patient decision aids in mainstreaming genetic testing for women with ovarian cancer: A prospective cohort study. | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2023 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. | |
dc.identifier.doi | 10.1111/1471-0528.17675 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/37752678 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
dcterms.dateAccepted | 2023-09-05 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |