Characterisation of a novel bioactive strontium-based endodontic sealant
View/ Open
Metadata
Show full item recordAbstract
Aims: The aim of this study was to design and synthesise a novel bioactive endodontic sealant that contains a bioactive glass (BAG) with strontium and fluoride embedded in a polydimethylsiloxane (PDMS) matrix. The physical and chemical properties of this sealant were compared with a commercially available, bioactive, endodontic sealant, Guttaflow Bioseal® (GFBS). Method: Physical properties were tested for both sealants against the International Organisation for Standardisation (ISO) 6876 and included: radiopacity, solubility, setting time and flow value. Chemical properties were also assessed after immersion of both sealants in simulated body fluid (SBF) and tris buffer solution (TBS). The following were analysed: pH rise, ion release (via inductively coupled plasma optical emission spectrometry (ICP-OES)) and apatite formation (via Fourier-transform infrared spectroscopy (FTIR) and X-Ray Diffraction (XRD)). Results: Both sealants demonstrated physical properties that met ISO 6876. The novel sealant illustrated improved physical properties (higher radio-opacity, lower solubility, and increased setting time). The rate of the Na+ ion release from GFBS was greater than 50 times that of the novel sealant. This explains why the solubility was higher from the GFBS® than from the novel sealant. The flow values for both sealants appeared similar. Both sealants showed an increase in pH over a period of three months, after immersion in solution. A higher pH rise was seen in GFBS®. Both sealants showed ion release (Ca, Na, P and Si), with additional Sr release from the novel sealant. Strontium has been associated with upregulation of osteoblast and 13 downregulation of osteoclast. GFBS had evidence of apatite formation after a 3-month immersion period in SBF, as seen from XRD analysis. Conclusion: Both the novel sealant and the GFBS® demonstrated bioactive properties with ion release from both sealants and the ultimate formation of apatite from GFBS®. The novel sealant showed improved physical properties with the addition of strontium increasing radiopacity and the reduction of sodium in the bioactive glass minimising the solubility of the sealant.
Authors
Parekh, SCollections
- Theses [4235]