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Theses [4190]
Theses Awarded by Queen Mary University of London
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Few-shot Claim Verification for Automated Fact Checking
In an era characterized by the rapid expansion of online information and the widespread dissemination of misinformation, automated fact-checking has emerged as an essential area of research. As digital platforms continue ... -
IP-Related Technical Assistance: Lessons for developing countries
(Queen Mary University of London, 2011)This thesis highlights the fact that intellectual property (IP) related technical assistance available and provided to developing countries thus far has focussed on aspects of enforcement of intellectual property rights ... -
Using a pathway dynamics approach to characterise the role of ions, accessory proteins and ligands on G protein-coupled receptor signalling.
Accessory proteins and ions are able to modulate the signalling mechanisms of certain GPCRs, and it’s been established that accessory proteins are necessary for processes such as receptor trafficking to the membrane, ligand ... -
Developing a database and geostatistical methods to study the epidemiology of PIBD
Inflammatory bowel diseases (IBD) are chronic idiopathic disorders that cause inflammation of the gastrointestinal tract. These chronic conditions affect over 2.5 million people in Europe alone, with a direct healthcare ... -
Improving Content Moderation in the Fediverse
The Fediverse is experiencing a growth in popularity, becoming a viable alternative to Twitter and other “centralised” social networks. The recent acquisition of Twitter by Elon Musk, which has sparked controversy, has ... -
Resident memory T cells in health and inflammatory bowel disease
Resident memory T cells (Trm) are a population of long-lived T-lymphocytes which persist in tissues and can contribute to inflammation. A small fraction can re-enter the circulation (ex-Trm) and give rise to new effector ... -
From Bees to Robots: A Statistical Mechanics Framework for Modelling Shimmering Dynamics and Control of Swarm Systems
While self-organised complex systems in nature continually provide inspiration for the burgeoning field of swarm robotics, the intriguing phenomenon of bee shimmering, referring to the emergent patterns formed by bees on ... -
Exploring the potential of specialized pro-resolving mediator biology in understanding the development and progression of inflammatory diseases using bioinformatics
Uncontrolled inflammation, generated by the inability of the host to initiate resolution mechanisms, can lead to the development and progression of inflammatory conditions, such as rheumatoid arthritis (RA). Specialized ... -
Ferroelectric-enhanced photo-electrocatalysis: photophysics of ferroelectric and ferroelectric-coupled water splitting photoelectrodes
To secure a stable and abundant world for future generations, an alternative, sustainable energy source to fossil fuels must be explored and deployed as a matter of urgency. Solar water splitting utilises sunlight and water ... -
Evaluating and Enhancing Gameplay Behavioural Expressivity of Planning-Playing Artificial Intelligence for Automatic Playtesting
This thesis focuses on game-playing Artificial Intelligence (AI) for advancing fully-automated play-testing using Statistical Forward Planning (SFP) algo- rithms like Monte Carlo Tree Search (MCTS) and Rolling Horizon ... -
Clinical, Molecular and Microbial Changes Following Treatment of Periodontitis
Introduction. Periodontitis is a chronic multifactorial inflammatory disease associated with dysbiotic plaque biofilms and characterized by progressive destruction of the tooth‐supporting apparatus which when left untreated, ... -
Prognostic and Predictive Biomarkers in Urological Cancers
Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Receptor 2 (HER2) overexpression and high levels of VEGF ribonucleic acid (RNA) are associated with poor prognosis in UC. Here, we investigated the HER family of ... -
Amyloid-β Assembly and Ion-Channel Formation in Alzheimer's Disease
The molecular pathology of Alzheimer’s disease (AD) remains unclear, though it is widely acknowledged that AD is triggered by the accumulation of a small peptide, Amyloid-β (Aβ) in the brain, typically 40 to 42 amino acids ... -
Adrenergic regulation of IKs and impairment in the hereditary long QT syndrome
KCNQ1 co-assembles with KCNE1 at the cell surface membrane to the form IKs channel, which is responsible for repolarisation of the ventricular action potential in the human heart. The long QT 1 phenotype is caused by ... -
An Investigation of Smartphone-based Localization Techniques for Humans in Indoor Spaces
Indoor positioning still faces important challenges from its current mainstream contenders, to support accurate and energy-efficient positioning. Inertial sensors-based solutions have cumulative errors and drift issues, ... -
Environmental Sensitivity in Primary School Children
Individuals differ in their susceptibility to environmental influences, with some being more and some being less affected by variations in the quality of their environment. Much of the research on susceptibility—or ... -
Uncovering the selection on non-homologous end joining and homologous recombination for genome downsizing in polyploid plants
An analysis of over 10,000 plant genome sizes (GSs) indicates that most species have smaller genomes than expected given the incidence of polyploidy in their ancestries, suggesting selection for genome downsizing. Given ... -
Pharmacogenomics in diverse ancestry populations: implications for medication safety and efficacy, health equality and pharmacovigilance
Background: Personalized prescribing with genetic information can decrease adverse drug reactions (ADRs) and increase therapeutic efficacy. Health inequality is a well acknowledged problem, and British south-Asians suffer ... -
Investigating Cardiomyocyte Dysfunction in Dilated Cardiomyopathy Associated with Duchenne Muscular Dystrophy
Mutations within the DMD gene are responsible for the severe, X-linked inherited disease Duchenne muscular dystrophy (DMD). DMD is characterised by the absence of the costameric protein, dystrophin, from striated muscle ... -
A sequence-based approach to identifying N2O fixing organisms
The increasing concentration of the powerful climate gas N2O has focussed research on its sources. In this thesis, I looked at the microbial ecology of experimental freshwater ponds that have been found to be a sink for ...
