dc.contributor.author | Liu, C | en_US |
dc.contributor.author | Pace, S | en_US |
dc.contributor.author | Bromley, R | en_US |
dc.contributor.author | Dobson, R | en_US |
dc.date.accessioned | 2023-09-01T15:06:30Z | |
dc.date.issued | 2023-09-01 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/90416 | |
dc.description.abstract | A range of long-term neurological conditions may be diagnosed in young adulthood. These conditions are generally not curable, and most people need to take ongoing treatment for symptom control and/or disease modification. When chronic diseases are diagnosed before people have completed their families, there is a need to balance the potential benefits of treatment for the mother against potential risk(s) to the fetus from exposure to medications during pregnancy. Whilst available data regarding short-term fetal outcomes following treatment exposures during pregnancy is rapidly increasing, information regarding longer-term outcomes is more limited. The association of fetal exposure to valproate with serious long-term neurodevelopmental outcomes has highlighted the importance of capturing and evaluating long-term data. In this review we examine available evidence around the long-term effects of treatments used for the most common long-term neurological conditions diagnosed in early adulthood, namely epilepsy, migraine and neuroinflammatory disorders. We draw from existing literature across a range of diseases and discuss strategies to improve future knowledge. | en_US |
dc.relation.ispartof | eClinicalMedicine | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.title | Exposure to medication for neurological disease in pregnancy – time to consider the long-term implications? | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1016/j.eclinm.2023.102157 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 63 | en_US |