dc.contributor.author | Young, WJ | en_US |
dc.contributor.author | Haessler, J | en_US |
dc.contributor.author | Benjamins, J-W | en_US |
dc.contributor.author | Repetto, L | en_US |
dc.contributor.author | Yao, J | en_US |
dc.contributor.author | Isaacs, A | en_US |
dc.contributor.author | Harper, AR | en_US |
dc.contributor.author | Ramirez, J | en_US |
dc.contributor.author | Garnier, S | en_US |
dc.contributor.author | van Duijvenboden, S | en_US |
dc.contributor.author | Baldassari, AR | en_US |
dc.contributor.author | Concas, MP | en_US |
dc.contributor.author | Duong, T | en_US |
dc.contributor.author | Foco, L | en_US |
dc.contributor.author | Isaksen, JL | en_US |
dc.contributor.author | Mei, H | en_US |
dc.contributor.author | Noordam, R | en_US |
dc.contributor.author | Nursyifa, C | en_US |
dc.contributor.author | Richmond, A | en_US |
dc.contributor.author | Santolalla, ML | en_US |
dc.contributor.author | Sitlani, CM | en_US |
dc.contributor.author | Soroush, N | en_US |
dc.contributor.author | Thériault, S | en_US |
dc.contributor.author | Trompet, S | en_US |
dc.contributor.author | Aeschbacher, S | en_US |
dc.contributor.author | Ahmadizar, F | en_US |
dc.contributor.author | Alonso, A | en_US |
dc.contributor.author | Brody, JA | en_US |
dc.contributor.author | Campbell, A | en_US |
dc.contributor.author | Correa, A | en_US |
dc.contributor.author | Darbar, D | en_US |
dc.contributor.author | De Luca, A | en_US |
dc.contributor.author | Deleuze, J-F | en_US |
dc.contributor.author | Ellervik, C | en_US |
dc.contributor.author | Fuchsberger, C | en_US |
dc.contributor.author | Goel, A | en_US |
dc.contributor.author | Grace, C | en_US |
dc.contributor.author | Guo, X | en_US |
dc.contributor.author | Hansen, T | en_US |
dc.contributor.author | Heckbert, SR | en_US |
dc.contributor.author | Jackson, RD | en_US |
dc.contributor.author | Kors, JA | en_US |
dc.contributor.author | Lima-Costa, MF | en_US |
dc.contributor.author | Linneberg, A | en_US |
dc.contributor.author | Macfarlane, PW | en_US |
dc.contributor.author | Morrison, AC | en_US |
dc.contributor.author | Navarro, P | en_US |
dc.contributor.author | Porteous, DJ | en_US |
dc.contributor.author | Pramstaller, PP | en_US |
dc.contributor.author | Reiner, AP | en_US |
dc.contributor.author | Risch, L | en_US |
dc.contributor.author | Schotten, U | en_US |
dc.contributor.author | Shen, X | en_US |
dc.contributor.author | Sinagra, G | en_US |
dc.contributor.author | Soliman, EZ | en_US |
dc.contributor.author | Stoll, M | en_US |
dc.contributor.author | Tarazona-Santos, E | en_US |
dc.contributor.author | Tinker, A | en_US |
dc.contributor.author | Trajanoska, K | en_US |
dc.contributor.author | Villard, E | en_US |
dc.contributor.author | Warren, HR | en_US |
dc.contributor.author | Whitsel, EA | en_US |
dc.contributor.author | Wiggins, KL | en_US |
dc.contributor.author | Arking, DE | en_US |
dc.contributor.author | Avery, CL | en_US |
dc.contributor.author | Conen, D | en_US |
dc.contributor.author | Girotto, G | en_US |
dc.contributor.author | Grarup, N | en_US |
dc.contributor.author | Hayward, C | en_US |
dc.contributor.author | Jukema, JW | en_US |
dc.contributor.author | Mook-Kanamori, DO | en_US |
dc.contributor.author | Olesen, MS | en_US |
dc.contributor.author | Padmanabhan, S | en_US |
dc.contributor.author | Psaty, BM | en_US |
dc.contributor.author | Pattaro, C | en_US |
dc.contributor.author | Ribeiro, ALP | en_US |
dc.contributor.author | Rotter, JI | en_US |
dc.contributor.author | Stricker, BH | en_US |
dc.contributor.author | van der Harst, P | en_US |
dc.contributor.author | van Duijn, CM | en_US |
dc.contributor.author | Verweij, N | en_US |
dc.contributor.author | Wilson, JG | en_US |
dc.contributor.author | Orini, M | en_US |
dc.contributor.author | Charron, P | en_US |
dc.contributor.author | Watkins, H | en_US |
dc.contributor.author | Kooperberg, C | en_US |
dc.contributor.author | Lin, HJ | en_US |
dc.contributor.author | Wilson, JF | en_US |
dc.contributor.author | Kanters, JK | en_US |
dc.contributor.author | Sotoodehnia, N | en_US |
dc.contributor.author | Mifsud, B | en_US |
dc.contributor.author | Lambiase, PD | en_US |
dc.contributor.author | Tereshchenko, LG | en_US |
dc.contributor.author | Munroe, PB | en_US |
dc.date.accessioned | 2023-06-05T11:02:15Z | |
dc.date.available | 2023-02-26 | en_US |
dc.date.issued | 2023-03-14 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/88700 | |
dc.description.abstract | The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction. | en_US |
dc.format.extent | 1411 - ? | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Nat Commun | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | Humans | en_US |
dc.subject | Cardiovascular Diseases | en_US |
dc.subject | Atrioventricular Block | en_US |
dc.subject | Genome-Wide Association Study | en_US |
dc.subject | Risk Factors | en_US |
dc.subject | Arrhythmias, Cardiac | en_US |
dc.subject | Electrocardiography | en_US |
dc.subject | Biomarkers | en_US |
dc.title | Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1038/s41467-023-36997-w | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/36918541 | en_US |
pubs.issue | 1 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 14 | en_US |
dcterms.dateAccepted | 2023-02-26 | en_US |
qmul.funder | The genetic architecture of heart rate and the electrocardiogram at rest and during exercise::Medical Research Council | en_US |
qmul.funder | The genetic architecture of heart rate and the electrocardiogram at rest and during exercise::Medical Research Council | en_US |