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Vitamin D3 inhibits p38 MAPK and senescence-associated inflammatory mediator secretion by senescent fibroblasts that impacts immune responses during ageing.
Sayegh, S; Fantecelle, CH; Laphanuwat, P; Subramanian, P; Rustin, MHA; Gomes, DCO; Akbar, AN; Chambers, ES (Wiley Open Access, 2024-01-29)Vitamin D3 replacement in older insufficient adults significantly improves their antigen-specific varicella zoster virus (VZV) cutaneous immunity. However, the mechanisms involved in this enhancement of cutaneous immunity ... -
HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia
Rai, TS; Cole, JJ; Nelson, DM; Dikovskaya, D; Faller, WJ; Vizioli, MG; Hewitt, RN; Anannya, O; McBryan, T; Manoharan, I (2014-12-15) -
Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors.
Saunderson, EA; Stepper, P; Gomm, JJ; Hoa, L; Morgan, A; Allen, MD; Jones, JL; Gribben, JG; Jurkowski, TP; Ficz, G (2017-11-13)Aberrant promoter DNA hypermethylation is a hallmark of cancer; however, whether this is sufficient to drive cellular transformation is not clear. To investigate this question, we use a CRISPR-dCas9 epigenetic editing tool, ...