dc.contributor.author | Okoye, I | |
dc.contributor.author | Wang, L | |
dc.contributor.author | Pallmer, K | |
dc.contributor.author | Richter, K | |
dc.contributor.author | Ichimura, T | |
dc.contributor.author | Haas, R | |
dc.contributor.author | Crouse, J | |
dc.contributor.author | Choi, O | |
dc.contributor.author | Heathcote, D | |
dc.contributor.author | Lovo, E | |
dc.contributor.author | Mauro, C | |
dc.contributor.author | Abdi, R | |
dc.contributor.author | Oxenius, A | |
dc.contributor.author | Rutschmann, S | |
dc.contributor.author | Ashton-Rickardt, PG | |
dc.date.accessioned | 2015-06-25T14:19:24Z | |
dc.date.issued | 2015-04-16 | |
dc.date.issued | 2015-05-29 | |
dc.date.issued | 2015-05-29 | |
dc.date.issued | 2015-05-29 | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/7782 | |
dc.description | The final published version of this paper can be found here http://dx.doi.org/10.1126/science.aaa7516 | |
dc.description.abstract | Protective CD8(+) T cell-mediated immunity requires a massive expansion in cell number and the development of long-lived memory cells. Using forward genetics in mice, we identified an orphan protein named lymphocyte expansion molecule (LEM) that promoted antigen-dependent CD8(+) T cell proliferation, effector function, and memory cell generation in response to infection with lymphocytic choriomeningitis virus. Generation of LEM-deficient mice confirmed these results. Through interaction with CR6 interacting factor (CRIF1), LEM controlled the levels of oxidative phosphorylation (OXPHOS) complexes and respiration, resulting in the production of pro-proliferative mitochondrial reactive oxygen species (mROS). LEM provides a link between immune activation and the expansion of protective CD8(+) T cells driven by OXPHOS and represents a pathway for the restoration of long-term protective immunity based on metabolically modified cytotoxic CD8(+) T cells. | |
dc.description.uri | http://dx.doi.org/10.1126/science.aaa7516 | |
dc.format.extent | 995 - 1001 | |
dc.language | ENG | |
dc.relation.ispartof | Science | |
dc.subject | Animals | |
dc.subject | CD8-Positive T-Lymphocytes | |
dc.subject | Cell Cycle Proteins | |
dc.subject | Cell Respiration | |
dc.subject | Immunity, Cellular | |
dc.subject | Immunologic Memory | |
dc.subject | Lymphocytic Choriomeningitis | |
dc.subject | Lymphocytic choriomeningitis virus | |
dc.subject | Mice | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | Mice, Knockout | |
dc.subject | Mitochondria | |
dc.subject | Mitochondrial Proteins | |
dc.subject | Molecular Sequence Data | |
dc.subject | Oxidative Phosphorylation | |
dc.subject | Reactive Oxygen Species | |
dc.title | T cell metabolism. The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration. | |
dc.type | Journal Article | |
dc.identifier.doi | 10.1126/science.aaa7516 | |
dc.relation.isPartOf | Science | |
dc.relation.isPartOf | Science | |
dc.relation.isPartOf | Science | |
pubs.author-url | http://www.ncbi.nlm.nih.gov/pubmed/25883318 | |
pubs.declined | 2015-04-30T09:36:40.781+0100 | |
pubs.issue | 6238 | |
pubs.publication-status | Published | |
pubs.volume | 348 | |