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dc.contributor.authorPhan, Hen_US
dc.contributor.authorMikkelsen, Ken_US
dc.contributor.authorChen, OYen_US
dc.contributor.authorKoch, Pen_US
dc.contributor.authorMertins, Aen_US
dc.contributor.authorDe Vos, Men_US
dc.date.accessioned2022-02-03T15:34:28Z
dc.date.issued2022-08en_US
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/76605
dc.description.abstractBACKGROUND: Black-box skepticism is one of the main hindrances impeding deep-learning-based automatic sleep scoring from being used in clinical environments. METHODS: Towards interpretability, this work proposes a sequence-to-sequence sleep-staging model, namely SleepTransformer. It is based on the transformer backbone and offers interpretability of the model's decisions at both the epoch and sequence level. We further propose a simple yet efficient method to quantify uncertainty in the model's decisions. The method, which is based on entropy, can serve as a metric for deferring low-confidence epochs to a human expert for further inspection. RESULTS: Making sense of the transformer's self-attention scores for interpretability, at the epoch level, the attention scores are encoded as a heat map to highlight sleep-relevant features captured from the input EEG signal. At the sequence level, the attention scores are visualized as the influence of different neighboring epochs in an input sequence (i.e. the context) to recognition of a target epoch, mimicking the way manual scoring is done by human experts. CONCLUSION: Additionally, we demonstrate that SleepTransformer performs on par with existing methods on two databases of different sizes. SIGNIFICANCE: Equipped with interpretability and the ability of uncertainty quantification, SleepTransformer holds promise for being integrated into clinical settings.en_US
dc.format.extent2456 - 2467en_US
dc.languageengen_US
dc.relation.ispartofIEEE Trans Biomed Engen_US
dc.subjectElectroencephalographyen_US
dc.subjectHumansen_US
dc.subjectPolysomnographyen_US
dc.subjectSleepen_US
dc.subjectSleep Stagesen_US
dc.subjectUncertaintyen_US
dc.titleSleepTransformer: Automatic Sleep Staging With Interpretability and Uncertainty Quantification.en_US
dc.typeArticle
dc.identifier.doi10.1109/TBME.2022.3147187en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35100107en_US
pubs.issue8en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume69en_US


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