dc.contributor.author | Wang, N | |
dc.contributor.author | Wang, J | |
dc.contributor.author | Zhang, Z | |
dc.contributor.author | Cao, H | |
dc.contributor.author | Yan, W | |
dc.contributor.author | Chu, Y | |
dc.contributor.author | Dunmall, LSC | |
dc.contributor.author | Wang, Y | |
dc.date.accessioned | 2021-11-04T10:41:26Z | |
dc.date.available | 2020-11-11 | |
dc.date.available | 2021-11-04T10:41:26Z | |
dc.date.issued | 2021-03-26 | |
dc.identifier.issn | 2372-7705 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/75019 | |
dc.description.abstract | Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world, and there remains an urgent
need to develop long-lasting therapies to treat CRC and prevent
recurrence in patients. Oncolytic virus therapy (OVT) has
demonstrated remarkable efficacy in a number of different
cancer models. Here, we report a novel vaccinia virus (VV)-
based OVT for treatment of CRC. The novel VV, based
on the recently reported novel VVLDTKDN1L virus, was
armed with the pleiotropic cytokine interleukin-21 (IL-21) to
enhance anti-tumor immune responses stimulated after viral
infection of tumor cells. Compared with an unarmed virus,
VVLDTKDN1L-mIL-21 had a superior anti-tumor efficacy in
murine CMT93 subcutaneous CRC models in vivo, mediated
mainly by CD8+ T cells. Treatment resulted in development
of long-term immunity against CMT93 tumor cells, as evidenced by prevention of disease recurrence. These results
demonstrate that VVLDTKDN1L-mIL-21 is a promising therapeutic agent for treatment of CRC. | en_US |
dc.format.extent | 71 - 81 | |
dc.publisher | Elsevier (Cell Press) | en_US |
dc.relation.ispartof | MOLECULAR THERAPY-ONCOLYTICS | |
dc.rights | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |
dc.title | A novel vaccinia virus enhances anti-tumor efficacy and promotes a long-term anti-tumor response in a murine model of colorectal cancer | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2020 Zhengzhou University and Queen Mary University of London. | |
dc.identifier.doi | 10.1016/j.omto.2020.11.002 | |
pubs.author-url | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000635158900008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6a | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.publisher-url | http://doi.org/10.1016/j.omto.2020.11.002 | |
pubs.volume | 20 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |