dc.contributor.author | Madurasinghe, VW | |
dc.contributor.author | Bower, P | |
dc.contributor.author | Eldridge, S | |
dc.contributor.author | Collier, D | |
dc.contributor.author | Graffy, J | |
dc.contributor.author | Treweek, S | |
dc.contributor.author | Knapp, P | |
dc.contributor.author | Parker, A | |
dc.contributor.author | Rick, J | |
dc.contributor.author | Salisbury, C | |
dc.contributor.author | Man, MS | |
dc.contributor.author | Torgerson, D | |
dc.contributor.author | Sheridan, R | |
dc.contributor.author | Sullivan, F | |
dc.contributor.author | Cockayne, S | |
dc.contributor.author | Dack, C | |
dc.date.accessioned | 2021-10-14T13:00:08Z | |
dc.date.available | 2021-08-04 | |
dc.date.available | 2021-10-14T13:00:08Z | |
dc.date.issued | 2021-09-23 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/74540 | |
dc.description.abstract | BACKGROUND: The information given to people considering taking part in a trial needs to be easy to understand if those people are to become, and then remain, trial participants. However, there is a tension between providing comprehensive information and providing information that is comprehensible. User-testing is one method of developing better participant information, and there is evidence that user-tested information is better at informing participants about key issues relating to trials. However, it is not clear if user-testing also leads to changes in the rates of recruitment in trials, compared to standard trial information. As part of a programme of research, we embedded 'studies within a trial' (SWATs) across multiple ongoing trials to see if user-tested materials led to better rates of recruitment. METHODS: Seven 'host' trials included a SWAT evaluation and randomised their participants to receive routine information sheets generated by the research teams, or information sheets optimised through user-testing. We collected data on trial recruitment and analysed the results across these trials using random effects meta-analysis, with the primary outcome defined as the proportion of participants randomised in a host trial following an invitation to take part. RESULTS: Six SWATs (n=27,805) provided data on recruitment. Optimised participant information sheets likely result in little or no difference in recruitment rates (7.2% versus 6.8%, pooled odds ratio = 1.03, 95% CI 0.90 to 1.19, p-value = 0.63, I2 = 0%). CONCLUSIONS: Participant information sheets developed through user testing did not improve recruitment rates. The programme of work showed that co-ordinated testing of recruitment strategies using SWATs is feasible and can provide both definitive and timely evidence on the effectiveness of recruitment strategies. TRIAL REGISTRATION: Healthlines Depression (ISRCTN14172341) Healthlines CVD (ISRCTN27508731) CASPER (ISRCTN02202951) ISDR (ISRCTN87561257) ECLS (NCT01925625) REFORM (ISRCTN68240461) HeLP Diabetes (ISRCTN02123133). | en_US |
dc.format.extent | 218 - ? | |
dc.language | eng | |
dc.relation.ispartof | BMC Med | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | Information | en_US |
dc.subject | Randomised controlled trial | en_US |
dc.subject | Recruitment | en_US |
dc.subject | Research methodology | en_US |
dc.subject | SWATs | en_US |
dc.subject | User-testing | en_US |
dc.title | Can we achieve better recruitment by providing better information? Meta-analysis of 'studies within a trial' (SWATs) of optimised participant information sheets. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1186/s12916-021-02086-2 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/34551765 | en_US |
pubs.issue | 1 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 19 | en_US |
dcterms.dateAccepted | 2021-08-04 | |
qmul.funder | Systematic Techniques for Assessing Recruitment to Trials (START): a programme to test recruitment interventions::Medical Research Council | en_US |